Carbon Nanotubes Encapsulated in Coiled‐Coil Peptide Barrels

Specific functionalization of 1D nanomaterials such as near infrared (nIR) fluorescent single‐walled carbon nanotubes (SWCNTs) is essential for colloidal stability and tailoring of their interactions with the environment. Here, we show that de novo designed alpha‐helical coiled‐coil peptide barrels...

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Bibliographic Details
Published in:Chemistry : a European journal 2018-08, Vol.24 (47), p.12241-12245
Main Authors: Mann, Florian A., Horlebein, Jan, Meyer, Nils Frederik, Meyer, Daniel, Thomas, Franziska, Kruss, Sebastian
Format: Article
Language:English
Subjects:
Atomic beam spectroscopy
Atomic force microscopy
Barrels
biosensors
carbon
Chemistry
coiled coil
Coils
Drug delivery
Drug delivery systems
Encapsulation
Fluorescence
Fluorescence spectroscopy
Medical imaging
Microscopy
Nanomaterials
Nanotechnology
Nanotubes
Peptides
Pores
Single wall carbon nanotubes
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Summary:Specific functionalization of 1D nanomaterials such as near infrared (nIR) fluorescent single‐walled carbon nanotubes (SWCNTs) is essential for colloidal stability and tailoring of their interactions with the environment. Here, we show that de novo designed alpha‐helical coiled‐coil peptide barrels (αHBs) with appropriate pores encapsulate and solubilize SWCNTs. In contrast, barrels without or with narrow pores showed a much smaller efficiency. Absorption/fluorescence spectroscopy and atomic force microscopy indicate that the SWCNTs are incorporated into the αHB′s pore. The resulting hybrid SWCNT@αHBs display periodic surface coverage with a 40 nm pitch and remain fluorescent in the nIR. This approach presents a novel concept to encapsulate, discriminate and functionalize SWCNTs non‐covalently with peptides and holds great promise for future applications in bioimaging or drug delivery. Rollin′, rollin′: De‐novo designed α‐helical coiled‐coil peptide barrels were used to encapsulate, solubilize and discriminate single‐walled carbon nanotubes. Different analytical techniques revealed a periodic surface‐coverage pattern. These α‐helical barrels can act as an anchoring platform for functional units around carbon nanotubes, which opens up new avenues for their application.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201800993