Expression of Sphingosine Kinase-1 Is Associated with Invasiveness and Poor Prognosis of Oral Squamous Cell Carcinoma

The expression of sphingosine kinase-1 (SphK1) has been reported in several cancers. However, the exact roles of SphK1 in cancer progression still remain unknown. The aim of the present study was to investigate SphK1 expression in oral squamous cell carcinoma (OSCC) and clarify the involvement of Sp...

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Bibliographic Details
Published in:Anticancer research 2018-03, Vol.38 (3), p.1361-1368
Main Authors: Kato, Koichiro, Shimasaki, Miyako, Kato, Takao, Segami, Natsuki, Ueda, Yoshimichi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Blotting, Western
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - pathology
E-cadherin
Female
Humans
Immunohistochemistry
Invasiveness
Kaplan-Meier Estimate
Kinases
Male
Medical prognosis
Mesenchyme
Middle Aged
Mouth Neoplasms - enzymology
Mouth Neoplasms - pathology
Multivariate Analysis
Neoplasm Invasiveness
Oral cancer
Oral squamous cell carcinoma
Phosphotransferases (Alcohol Group Acceptor) - biosynthesis
Prognosis
Sphingosine kinase
Squamous cell carcinoma
Tumor cells
Tumors
Vimentin
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Summary:The expression of sphingosine kinase-1 (SphK1) has been reported in several cancers. However, the exact roles of SphK1 in cancer progression still remain unknown. The aim of the present study was to investigate SphK1 expression in oral squamous cell carcinoma (OSCC) and clarify the involvement of SphK1 in the proliferation and invasiveness of OSCC and its prognostic implications. Expression of SphK1, E-cadherin, vimentin, and Ki-67 were examined in 69 OSCC tissues immunohistochemically, as well as by western blot, and correlations between their expression and relationships with tumor invasiveness and prognosis were analyzed. SphK1 was expressed in the tumor cells of 38 of 69 OSCCs, particularly at the invasion front. Patients with OSCCs with high SphK1 expression showed higher invasive grades and unfavorable survival rates. SphK1 expression correlated with acquisition of vimentin expression and loss of E-cadherin expression; there was no significant difference in Ki-67 labeling indices between OSCCs with high and low SphK1 expression. These results demonstrate the involvement of SphK1 in the invasiveness of OSCC and in unfavorable prognosis, indicating its role in the epithelial-mesenchymal transition of OSCC cells.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.12359