Holoprosencephaly: morphological aspects of twelve cases of autopsy

The term holoprosencephaly (HPC) is used to indicate the group of hemispheric deformities caused by a failure in the development of the prosencephalic vesicle. The purpose of this study is to explain the morphologic spector of twelve cases of HPC, qualify them, and compare them to the literature. It...

Full description

Saved in:
Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2001-12, Vol.59 (4), p.913-919
Main Authors: Noronha, L, Ghanem, R C, Medeiros, F, Knopfholz, J, Magalhães, T A, Sampaio, G A, Serapião, M J, Torres, L F
Format: Article
Language:eng ; por
Subjects:
Age Distribution
Age Factors
Brazil
Female
Holoprosencephaly - pathology
Humans
Infant
Infant, Newborn
Male
Sex Distribution
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The term holoprosencephaly (HPC) is used to indicate the group of hemispheric deformities caused by a failure in the development of the prosencephalic vesicle. The purpose of this study is to explain the morphologic spector of twelve cases of HPC, qualify them, and compare them to the literature. It was evaluated 5837 pediatrics necropsies, and there were 12 cases of HPC. Data like gender, age and the presence of another associated malformations were evaluated and compared to another malformations and to the total number of necropsies. The majority of the cases was male (66.66%), and stillborns (75%). The most frequently type of HPC found was the lobar type (58.3%), and the most frequently type of facial alteration was the ciclopy (25%). There is a statistic tendency to HPC affect the male sex, in comparison with other neurologic malformations. Besides, the stillborns are more frequently observed in HPC than in other neurologic malformations.
ISSN:0004-282X
DOI:10.1590/S0004-282X2001000600014