Influence of Ulipristal Acetate Therapy on Uterine Fibroid‐Related Symptoms and on Uterine and Fibroid Volumes and Vascularity Indices Assessed by Ultrasound

Objectives To investigate the modifications of uterine and fibroid volume, to study Doppler changes in uterine arteries and fibroid‐supplying vessels, and to assess possible symptomatic relief after 3 months of treatment with ulipristal acetate. Methods Forty‐two premenopausal women with symptomatic...

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Bibliographic Details
Published in:Journal of ultrasound in medicine 2018-09, Vol.37 (9), p.2215-2223
Main Authors: Baggio, Silvia, Pomini, Paola, Galeone, Fabiana, Presti, Francesca, Santi, Lorenza, Raffaelli, Ricciarda, Franchi, Massimo
Format: Article
Language:English
Subjects:
Adult
Contraceptive Agents, Female - therapeutic use
Doppler (techniques/physics)
Female
fibroids
Humans
Leiomyoma - blood supply
Leiomyoma - diagnostic imaging
Leiomyoma - drug therapy
Longitudinal Studies
Middle Aged
Norpregnadienes - therapeutic use
Organ Size
Prospective Studies
Treatment Outcome
ulipristal acetate
Ultrasonography, Doppler - methods
ultrasound techniques/physics
Uterus - blood supply
Uterus - diagnostic imaging
Uterus - pathology
vascularization
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Summary:Objectives To investigate the modifications of uterine and fibroid volume, to study Doppler changes in uterine arteries and fibroid‐supplying vessels, and to assess possible symptomatic relief after 3 months of treatment with ulipristal acetate. Methods Forty‐two premenopausal women with symptomatic fibroids were included in the study. They were evaluated clinically for the symptoms reported and underwent ultrasound examinations before starting treatment and after 3 months of therapy with ulipristal acetate. Transvaginal scanning was performed by the same sonographer, who measured the uterine volume and uterine artery pulsatility index and resistive index. Considering that some patients had more than 1 fibroid, the vascularization (supplying vessel pulsatility and resistive indices), locations, and sizes of a total of 73 fibroids were also recorded. Results After 3 months of ulipristal acetate, patients had a significant improvement of all symptoms (P 
ISSN:0278-4297
1550-9613
DOI:10.1002/jum.14573