OnabotulinumtoxinA treatment of moderate to severe glabellar lines in Chinese subjects after laser therapy: A prospective, open-label, noncomparative study

This study evaluated safety and efficacy of onabotulinumtoxinA for moderate to severe glabellar lines (GL) following laser therapy in Chinese subjects. Subjects (n = 173) were followed for 120 days following a single onabotulinumtoxinA (20 U) treatment for GL after recent laser therapy. Subjects com...

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Bibliographic Details
Published in:Journal of cosmetic and laser therapy 2018-10, Vol.20 (5), p.278-286
Main Authors: Wu, Yan, Lu, Zhong, Xie, Yong, Zhang, Wei, Chen, Xiangdong, Shi, Yuling, Li, Qin, Halstead, Michael, Rogers, John D, Silberberg, Michael
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group
Botulinum Toxins, Type A - adverse effects
Botulinum Toxins, Type A - therapeutic use
China
Female
Forehead
Humans
Laser Therapy
Male
Middle Aged
Neuromuscular Agents - adverse effects
Neuromuscular Agents - therapeutic use
Patient Reported Outcome Measures
Patient Satisfaction
Prospective Studies
Rhytidoplasty - methods
Skin Aging - drug effects
Skin Aging - radiation effects
Treatment Outcome
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Summary:This study evaluated safety and efficacy of onabotulinumtoxinA for moderate to severe glabellar lines (GL) following laser therapy in Chinese subjects. Subjects (n = 173) were followed for 120 days following a single onabotulinumtoxinA (20 U) treatment for GL after recent laser therapy. Subjects completed validated patient-reported outcomes, including Facial Lines Outcome 11-item (FLO-11) Questionnaire and Facial Lines Satisfaction Questionnaire (FLSQ). Physicians and subjects assessed GL severity at maximum frown and at rest using the Facial Wrinkle Scale with Asian Photonumeric Guide (FWS-A). Mean total FLO-11 scores increased from 47.7 (baseline) to 75.9 (day 120) (p 
ISSN:1476-4172
1476-4180
DOI:10.1080/14764172.2017.1406604