Serum tenascin-C predicts severity and outcome of acute intracerebral hemorrhage

• Published in: Clinica chimica acta 2018-06, Vol.481, p.69-74
• Main Authors: Wang, Lin-Guo, Huangfu, Xue-Qin, Tao, Bo, Zhong, Guan-Jin, Le, Zhou-Di
• Format: Article
• Language: English
• Subjects: Intracerebral hemorrhage; Outcome; Severity; Tenascin-C
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2018.02.033

Tenascin-C is a matricellular protein related to brain injury. We studied serum tenascin-C in acute intracerebral hemorrhage (ICH) and examined the associations with severity and outcome following the acute event. Tenascin-C samples were obtained from 162 patients with acute hemorrhagic stroke and 162 healthy controls. Poor 90-day functional outcome was defined as modified Rankin Scale score > 2. Early neurological deterioration (END) and hematoma growth (HG) were recorded at 24 h. Patients had higher tenascin-C levels than controls. Tenascin-C levels were positively correlated with hematoma volume or National Institutes of Health Stroke Scale score at baseline. Elevated tenascin-C levels were independently associated with END, HG, 90-day mortality and poor functional outcome. Moreover, tenascin-C levels significantly predicted END, HG and 90-day outcomes under receiver operating characteristic curves. An increase in serum tenascin-C level is associated with an adverse outcome in ICH patients, supporting the potential role of serum tenascin-C as a prognostic biomarker for hemorrhagic stroke. •Serum tenascin-C levels are increased after hemorrhagic stroke.•Serum tenascin-C levels are relevant to hemorrhagic severity.•Serum tenascin-C has independent relation to a poor prognosis after hemorrhagic stroke.•Serum tenascin-C levels possess significant prognostic ability for hemorrhagic stroke