Small Renal Masses in Close Proximity to the Collecting System and Renal Sinus Are Enriched for Malignancy and High Fuhrman Grade and Should Be Considered for Early Intervention

The small renal mass is a heterogeneous entity that needs careful consideration before treatment selection. Merging radiographic and clinical-pathological data from 334 patients we aimed to assess if renal mass anatomical characteristics were associated with malignancy and high-grade histology. Near...

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Bibliographic Details
Published in:Clinical genitourinary cancer 2018-08, Vol.16 (4), p.e729-e733
Main Authors: Correa, Andres F., Toussi, Amir, Amin, Milon, Hrebinko, Ronald L., Gayed, Bishoy A., Parwani, Anil V., Maranchie, Jodi K.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Early Medical Intervention - methods
Female
High Grade
Histology
Humans
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Location
Logistic Models
Male
Middle Aged
Neoplasm Staging
Nephrectomy
Odds Ratio
Renal cell carcinoma
Retrospective Studies
Small renal mass
Young Adult
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Summary:The small renal mass is a heterogeneous entity that needs careful consideration before treatment selection. Merging radiographic and clinical-pathological data from 334 patients we aimed to assess if renal mass anatomical characteristics were associated with malignancy and high-grade histology. Nearness to the collecting system was the only variable found to be associated with the diagnosis of cancer and high-grade disease. Recent reports show a correlation between renal tumor radiographic characteristics and pathologic features. We hypothesize that a more central location within the relatively hypoxic renal medulla might confer a more aggressive tumor phenotype. To test this, radiographic tumor characteristics were compared with tumor grade and histology. We retrospectively reviewed renal masses 
ISSN:1558-7673
1938-0682
DOI:10.1016/j.clgc.2018.01.017