α-Tocopherol Reduces Morphological Changes and Oxidative Stress during Gentamicin-Induced Acute Renal Failure

We studied the effect of α-tocopherol on gentamicin-induced morphological and functional changes in the kidneys of Wistar rats. Special attention was paid to the ability of α-tocopherol administered in combination with gentamicin to correct ultrastructural changes in the glomerular basal membrane an...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-03, Vol.164 (4), p.442-445
Main Authors: Stojiljkovic, N., Ilic, S., Veljkovic, M., Todorovic, J., Mladenovic, M.
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - metabolism
Acute Kidney Injury - pathology
Acute Kidney Injury - prevention & control
alpha-Tocopherol - pharmacology
Animals
Antioxidants - pharmacology
Biomedical and Life Sciences
Biomedicine
Catalase - blood
Cell Biology
Gentamicin
Gentamicins - toxicity
Internal Medicine
Kidney Glomerulus - drug effects
Kidney Glomerulus - metabolism
Kidney Glomerulus - pathology
Kidney Tubules - drug effects
Kidney Tubules - metabolism
Kidney Tubules - pathology
Kidneys
Laboratory Medicine
Malondialdehyde - blood
Morphology
Oxidative stress
Oxidative Stress - drug effects
Pathology
Rats
Rats, Wistar
Renal failure
Rodents
Tubules
Vitamin E
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Summary:We studied the effect of α-tocopherol on gentamicin-induced morphological and functional changes in the kidneys of Wistar rats. Special attention was paid to the ability of α-tocopherol administered in combination with gentamicin to correct ultrastructural changes in the glomerular basal membrane and tubules. Combined treatment with α-tocopherol (100 mg/kg) and gentamicin (100 mg/kg) led to correction of histopathological and biochemical changes and oxidative injury to the kidneys induced by this antibiotic.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4008-y