Expression of miR-200c and its clinicopathological significance in patients with colorectal cancer

MicroRNA-200c (miR-200c) is known to play a pivotal role in the regulation of epithelial-to-mesenchymal and mesenchymal-to-epithelial transition processes. However, the biological function of miR-200c in human carcinogenesis remains controversial. We examined the association of miR-200c expression w...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2018-03, Vol.214 (3), p.350-355
Main Authors: Roh, Mee Sook, Lee, Hyoun Wook, Jung, Sang Bong, Kim, Kyungeun, Lee, Eun Hee, Park, Moon-il, Lee, Jae Seok, Kim, Mee-Seon
Format: Article
Language:English
Subjects:
Colorectal cancer
KRAS mutation
MicroRNA
miR-200c
Prognosis
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Summary:MicroRNA-200c (miR-200c) is known to play a pivotal role in the regulation of epithelial-to-mesenchymal and mesenchymal-to-epithelial transition processes. However, the biological function of miR-200c in human carcinogenesis remains controversial. We examined the association of miR-200c expression with various clinicopathological factors, including KRAS mutation status and survival, in patients with colorectal cancer (CRC). The expression level of miR-200c was evaluated in 109 paired CRC and normal tissue samples using quantitative reverse transcription polymerase chain reaction. The KRAS mutation status of the CRC samples was determined using the PNAClamp™ KRAS Mutation Detection kit. Compared with the normal tissue group, miR-200c expression was significantly upregulated in the CRCs (P 
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2018.01.005