Uneven Braking Spins RNA Polymerase into a Pause

In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA. In this issue of Mo...

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Bibliographic Details
Published in:Molecular cell 2018-03, Vol.69 (5), p.723-725
Main Authors: Artsimovitch, Irina, Belogurov, Georgiy A.
Format: Article
Language:English
Subjects:
DNA-Directed RNA Polymerases - genetics
Escherichia coli - genetics
Escherichia coli Proteins
Nucleic Acid Conformation
RNA, Bacterial
Transcription, Genetic
Transcriptional Elongation Factors
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Summary:In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA. In this issue of Molecular Cell, Guo et al. (2018) and Kang et al. (2018) report structures of paused transcription complexes in which asynchronous translocation inhibits nucleotide addition, allowing for global rearrangements in RNA polymerase stabilized by RNA hairpin and NusA.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2018.02.013