Improvements of ambient hyperglycemia and glycemic variability are associated with reduction in oxidative stress for patients with type 2 diabetes

•Improvements in daily and day-to-day glucose and oxidative stress are associated.•Glucose-like peptide 1 receptor agonists directly affect oxidative stress.•Statin relieves oxidative stress independent of improvements in lipids. We aimed to evaluate which parameters of improvement in glucose metabo...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2018-05, Vol.139, p.253-261
Main Authors: Ohara, Makoto, Nagaike, Hiroe, Goto, Satoshi, Fukase, Ayako, Tanabe, Yuki, Tomoyasu, Masako, Yamamoto, Takeshi, Hayashi, Toshiyuki, Fukui, Tomoyasu, Hirano, Tsutomu
Format: Article
Language:English
Subjects:
Diacron-reactive oxygen metabolites
Glucose monitoring
Glucose variability
Oxidative stress
Type 2 diabetes mellitus
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Summary:•Improvements in daily and day-to-day glucose and oxidative stress are associated.•Glucose-like peptide 1 receptor agonists directly affect oxidative stress.•Statin relieves oxidative stress independent of improvements in lipids. We aimed to evaluate which parameters of improvement in glucose metabolism reduce oxidative stress for patients with Type 2 diabetes mellitus (T2DM). Sixty-seven outpatients with T2DM underwent 72 h of continuous glucose monitoring (CGM) and were measured for oxidative stress before and after a 24-week intervention with the following targets: fasting plasma glucose (FPG),
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2018.02.017