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Improvements of ambient hyperglycemia and glycemic variability are associated with reduction in oxidative stress for patients with type 2 diabetes
•Improvements in daily and day-to-day glucose and oxidative stress are associated.•Glucose-like peptide 1 receptor agonists directly affect oxidative stress.•Statin relieves oxidative stress independent of improvements in lipids. We aimed to evaluate which parameters of improvement in glucose metabo...
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| Published in: | Diabetes research and clinical practice 2018-05, Vol.139, p.253-261 |
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| cites | cdi_FETCH-LOGICAL-c412t-8957521f2383734a1bf9364866396c075da8fbb5e1953e62bc751b6789f45463 |
| container_end_page | 261 |
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| container_start_page | 253 |
| container_title | Diabetes research and clinical practice |
| container_volume | 139 |
| creator | Ohara, Makoto Nagaike, Hiroe Goto, Satoshi Fukase, Ayako Tanabe, Yuki Tomoyasu, Masako Yamamoto, Takeshi Hayashi, Toshiyuki Fukui, Tomoyasu Hirano, Tsutomu |
| description | •Improvements in daily and day-to-day glucose and oxidative stress are associated.•Glucose-like peptide 1 receptor agonists directly affect oxidative stress.•Statin relieves oxidative stress independent of improvements in lipids.
We aimed to evaluate which parameters of improvement in glucose metabolism reduce oxidative stress for patients with Type 2 diabetes mellitus (T2DM).
Sixty-seven outpatients with T2DM underwent 72 h of continuous glucose monitoring (CGM) and were measured for oxidative stress before and after a 24-week intervention with the following targets: fasting plasma glucose (FPG), |
| doi_str_mv | 10.1016/j.diabres.2018.02.017 |
| format | article |
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We aimed to evaluate which parameters of improvement in glucose metabolism reduce oxidative stress for patients with Type 2 diabetes mellitus (T2DM).
Sixty-seven outpatients with T2DM underwent 72 h of continuous glucose monitoring (CGM) and were measured for oxidative stress before and after a 24-week intervention with the following targets: fasting plasma glucose (FPG), <130 mg/dl; postprandial plasma glucose (PPG), <180 mg/dl; and glycated hemoglobin (HbA1c), <7% (53 mmol/mol). The mean glucose level (MGL), mean amplitude of glycemic excursions (MAGE), mean of daily differences (MODD), percentage coefficient of variation for glucose (%CV) and area under the postprandial plasma glucose curve (AUCPP) were calculated from the CGM data. Oxidative stress was estimated using the diacron-reactive oxygen metabolites (d-ROMs) test. Finally, the association between the improvements in glucose metabolism and oxidative stress was evaluated.
FPG, MGL, HbA1c, MAGE, MODD, %CV, AUCPP, and d-ROMs significantly improved after 24 weeks of intervention. The change in d-ROMs was significantly correlated with that in FPG (r = 0.414), MGL (r = 0.402), HbA1c (r = 0.271), MAGE (r = 0.457), MODD (r = 0.371), and AUCPP (r = 0.352). The correlation of the change in d-ROMs with that in FPG, MAGE, and MODD and the use of glucose-like peptide 1 receptor agonists and statins remained significant after adjustment for other markers of diabetes control (multiple R2 = 0.406).
Improvements in glucose metabolism, including FPG and daily and day-to-day glucose variability, were all correlated with reduced oxidative stress for patients with T2DM.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2018.02.017</identifier><identifier>PMID: 29501829</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Diacron-reactive oxygen metabolites ; Glucose monitoring ; Glucose variability ; Oxidative stress ; Type 2 diabetes mellitus</subject><ispartof>Diabetes research and clinical practice, 2018-05, Vol.139, p.253-261</ispartof><rights>2018</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-8957521f2383734a1bf9364866396c075da8fbb5e1953e62bc751b6789f45463</citedby><cites>FETCH-LOGICAL-c412t-8957521f2383734a1bf9364866396c075da8fbb5e1953e62bc751b6789f45463</cites><orcidid>0000-0002-3676-9693</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29501829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohara, Makoto</creatorcontrib><creatorcontrib>Nagaike, Hiroe</creatorcontrib><creatorcontrib>Goto, Satoshi</creatorcontrib><creatorcontrib>Fukase, Ayako</creatorcontrib><creatorcontrib>Tanabe, Yuki</creatorcontrib><creatorcontrib>Tomoyasu, Masako</creatorcontrib><creatorcontrib>Yamamoto, Takeshi</creatorcontrib><creatorcontrib>Hayashi, Toshiyuki</creatorcontrib><creatorcontrib>Fukui, Tomoyasu</creatorcontrib><creatorcontrib>Hirano, Tsutomu</creatorcontrib><title>Improvements of ambient hyperglycemia and glycemic variability are associated with reduction in oxidative stress for patients with type 2 diabetes</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>•Improvements in daily and day-to-day glucose and oxidative stress are associated.•Glucose-like peptide 1 receptor agonists directly affect oxidative stress.•Statin relieves oxidative stress independent of improvements in lipids.
We aimed to evaluate which parameters of improvement in glucose metabolism reduce oxidative stress for patients with Type 2 diabetes mellitus (T2DM).
Sixty-seven outpatients with T2DM underwent 72 h of continuous glucose monitoring (CGM) and were measured for oxidative stress before and after a 24-week intervention with the following targets: fasting plasma glucose (FPG), <130 mg/dl; postprandial plasma glucose (PPG), <180 mg/dl; and glycated hemoglobin (HbA1c), <7% (53 mmol/mol). The mean glucose level (MGL), mean amplitude of glycemic excursions (MAGE), mean of daily differences (MODD), percentage coefficient of variation for glucose (%CV) and area under the postprandial plasma glucose curve (AUCPP) were calculated from the CGM data. Oxidative stress was estimated using the diacron-reactive oxygen metabolites (d-ROMs) test. Finally, the association between the improvements in glucose metabolism and oxidative stress was evaluated.
FPG, MGL, HbA1c, MAGE, MODD, %CV, AUCPP, and d-ROMs significantly improved after 24 weeks of intervention. The change in d-ROMs was significantly correlated with that in FPG (r = 0.414), MGL (r = 0.402), HbA1c (r = 0.271), MAGE (r = 0.457), MODD (r = 0.371), and AUCPP (r = 0.352). The correlation of the change in d-ROMs with that in FPG, MAGE, and MODD and the use of glucose-like peptide 1 receptor agonists and statins remained significant after adjustment for other markers of diabetes control (multiple R2 = 0.406).
Improvements in glucose metabolism, including FPG and daily and day-to-day glucose variability, were all correlated with reduced oxidative stress for patients with T2DM.</description><subject>Diacron-reactive oxygen metabolites</subject><subject>Glucose monitoring</subject><subject>Glucose variability</subject><subject>Oxidative stress</subject><subject>Type 2 diabetes mellitus</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v3CAURFWqZpP2J7R6x1zWAWwwPlVRlLaRIuWSO8Lw3LCyzRbYbfdv5BeX_UiuOfFAM2-YGUK-MloxyuT1qnLe9BFTxSlTFeUVZe0HsmCq5UvFeXtGFgWnDvM5uUhpRSmVdSM-kXPeiULi3YK83E_rGLY44ZwThAHM1Psyw_NujfH3uLM4eQNmdnC6WNiaWKT96PMOTEQwKQXrTUYHf31-hohuY7MPM_gZwj_vTPZbhJTLbxMMIcK6vBwED_hcpIDD3g9mTJ_Jx8GMCb-czkvy9OPu6fbX8uHx5_3tzcPSNoznpepEKzgbeK3qtm4M64eulo2Ssu6kpa1wRg19L5B1okbJe9sK1stWdUMjGllfkqvj2uL_zwZT1pNPFsfRzBg2SZdYadnMJC1QcYTaGFKKOOh19JOJO82o3rehV_rUxp6mNOW6tFF4304Sm35C98Z6jb8Avh8BWHxuPUadbAnGovMRbdYu-Hck_gMoK6B4</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Ohara, Makoto</creator><creator>Nagaike, Hiroe</creator><creator>Goto, Satoshi</creator><creator>Fukase, Ayako</creator><creator>Tanabe, Yuki</creator><creator>Tomoyasu, Masako</creator><creator>Yamamoto, Takeshi</creator><creator>Hayashi, Toshiyuki</creator><creator>Fukui, Tomoyasu</creator><creator>Hirano, Tsutomu</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3676-9693</orcidid></search><sort><creationdate>20180501</creationdate><title>Improvements of ambient hyperglycemia and glycemic variability are associated with reduction in oxidative stress for patients with type 2 diabetes</title><author>Ohara, Makoto ; Nagaike, Hiroe ; Goto, Satoshi ; Fukase, Ayako ; Tanabe, Yuki ; Tomoyasu, Masako ; Yamamoto, Takeshi ; Hayashi, Toshiyuki ; Fukui, Tomoyasu ; Hirano, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-8957521f2383734a1bf9364866396c075da8fbb5e1953e62bc751b6789f45463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Diacron-reactive oxygen metabolites</topic><topic>Glucose monitoring</topic><topic>Glucose variability</topic><topic>Oxidative stress</topic><topic>Type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohara, Makoto</creatorcontrib><creatorcontrib>Nagaike, Hiroe</creatorcontrib><creatorcontrib>Goto, Satoshi</creatorcontrib><creatorcontrib>Fukase, Ayako</creatorcontrib><creatorcontrib>Tanabe, Yuki</creatorcontrib><creatorcontrib>Tomoyasu, Masako</creatorcontrib><creatorcontrib>Yamamoto, Takeshi</creatorcontrib><creatorcontrib>Hayashi, Toshiyuki</creatorcontrib><creatorcontrib>Fukui, Tomoyasu</creatorcontrib><creatorcontrib>Hirano, Tsutomu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohara, Makoto</au><au>Nagaike, Hiroe</au><au>Goto, Satoshi</au><au>Fukase, Ayako</au><au>Tanabe, Yuki</au><au>Tomoyasu, Masako</au><au>Yamamoto, Takeshi</au><au>Hayashi, Toshiyuki</au><au>Fukui, Tomoyasu</au><au>Hirano, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvements of ambient hyperglycemia and glycemic variability are associated with reduction in oxidative stress for patients with type 2 diabetes</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>139</volume><spage>253</spage><epage>261</epage><pages>253-261</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>•Improvements in daily and day-to-day glucose and oxidative stress are associated.•Glucose-like peptide 1 receptor agonists directly affect oxidative stress.•Statin relieves oxidative stress independent of improvements in lipids.
We aimed to evaluate which parameters of improvement in glucose metabolism reduce oxidative stress for patients with Type 2 diabetes mellitus (T2DM).
Sixty-seven outpatients with T2DM underwent 72 h of continuous glucose monitoring (CGM) and were measured for oxidative stress before and after a 24-week intervention with the following targets: fasting plasma glucose (FPG), <130 mg/dl; postprandial plasma glucose (PPG), <180 mg/dl; and glycated hemoglobin (HbA1c), <7% (53 mmol/mol). The mean glucose level (MGL), mean amplitude of glycemic excursions (MAGE), mean of daily differences (MODD), percentage coefficient of variation for glucose (%CV) and area under the postprandial plasma glucose curve (AUCPP) were calculated from the CGM data. Oxidative stress was estimated using the diacron-reactive oxygen metabolites (d-ROMs) test. Finally, the association between the improvements in glucose metabolism and oxidative stress was evaluated.
FPG, MGL, HbA1c, MAGE, MODD, %CV, AUCPP, and d-ROMs significantly improved after 24 weeks of intervention. The change in d-ROMs was significantly correlated with that in FPG (r = 0.414), MGL (r = 0.402), HbA1c (r = 0.271), MAGE (r = 0.457), MODD (r = 0.371), and AUCPP (r = 0.352). The correlation of the change in d-ROMs with that in FPG, MAGE, and MODD and the use of glucose-like peptide 1 receptor agonists and statins remained significant after adjustment for other markers of diabetes control (multiple R2 = 0.406).
Improvements in glucose metabolism, including FPG and daily and day-to-day glucose variability, were all correlated with reduced oxidative stress for patients with T2DM.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29501829</pmid><doi>10.1016/j.diabres.2018.02.017</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3676-9693</orcidid><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals |
| subjects | Diacron-reactive oxygen metabolites Glucose monitoring Glucose variability Oxidative stress Type 2 diabetes mellitus |
| title | Improvements of ambient hyperglycemia and glycemic variability are associated with reduction in oxidative stress for patients with type 2 diabetes |
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