Assessment of treatment factors and clinical outcomes in cervical cancer in older women compared to women under 65 years old

This study aims to understand the treatment patterns and clinical outcomes of older women with cervical cancer compared to younger women. Women undergoing care for cervical cancer between 2000 and 2013 at two academic institutions were identified. The cohort of older patients was defined as >65 y...

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Published in:Journal of geriatric oncology 2018-09, Vol.9 (5), p.516-519
Main Authors: Diver, Elisabeth J., Hinchcliff, Emily M., Gockley, Allison A., Melamed, Alexander, Contrino, Leah, Feldman, Sarah, Growdon, Whitfield B.
Format: Article
Language:English
Subjects:
Cervical carcinoma
Chemoradiation
Elderly
Radical hysterectomy
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container_title Journal of geriatric oncology
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Hinchcliff, Emily M.
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Growdon, Whitfield B.
description This study aims to understand the treatment patterns and clinical outcomes of older women with cervical cancer compared to younger women. Women undergoing care for cervical cancer between 2000 and 2013 at two academic institutions were identified. The cohort of older patients was defined as >65 years old at diagnosis. Patient charts were retrospectively reviewed, and clinical variables were extracted. Fisher's exact tests, logistic regression, and Kaplan-Meier analyses were performed. From 2000 to 2013 1119 women with cervical cancer were identified. Of these, 191 (17.0%) were >65 years old at the time of diagnosis. Older women were more likely to present with higher stage disease (p 
doi_str_mv 10.1016/j.jgo.2018.02.004
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Women undergoing care for cervical cancer between 2000 and 2013 at two academic institutions were identified. The cohort of older patients was defined as &gt;65 years old at diagnosis. Patient charts were retrospectively reviewed, and clinical variables were extracted. Fisher's exact tests, logistic regression, and Kaplan-Meier analyses were performed. From 2000 to 2013 1119 women with cervical cancer were identified. Of these, 191 (17.0%) were &gt;65 years old at the time of diagnosis. Older women were more likely to present with higher stage disease (p &lt; 0.001). Controlling for stage, older women were less likely to undergo surgery during their treatment course (38% versus 70%, p &lt; 0.001) and more likely to undergo radiation (77% versus 52%, p &lt; 0.001), but no more likely to receive chemotherapy (p = 0.34). If they did undergo surgery, older women were less likely to have a pelvic lymph node dissection performed (41% versus 61%, p = 0.04), though the rate of positive pelvic lymph nodes was not different (p = 0.80). Overall survival was decreased in the older cohort (p &lt; 0.001). A multivariate model identified age &gt; 65 (HR 1.76, 95%CI 1.30–2.40), stage (HR 2.77, 95%CI 2.40–3.21), and ever undergoing surgery (HR 0.60, 95%CI 0.44–0.82) as independently associated with overall survival. 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subjects Cervical carcinoma
Chemoradiation
Elderly
Radical hysterectomy
title Assessment of treatment factors and clinical outcomes in cervical cancer in older women compared to women under 65 years old
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