Purification and identification of anti-inflammatory peptides from spent hen muscle proteins hydrolysate

•Anti-inflammatory peptides were produced from spent hen muscle proteins.•17 peptide sequences from muscle proteins were identified.•Peptide FLWGKSY showed the best anti-inflammatory activity in vitro.•Peptides derived from hen muscle can be used for anti-inflammatory applications. Spent hens have l...

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Bibliographic Details
Published in:Food chemistry 2018-07, Vol.253, p.101-107
Main Authors: Yu, Wenlin, Field, Catherine J., Wu, Jianping
Format: Article
Language:English
Subjects:
Anti-inflammatory peptides
Identification
Mass spectrometry
Purification
Spent hen
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Summary:•Anti-inflammatory peptides were produced from spent hen muscle proteins.•17 peptide sequences from muscle proteins were identified.•Peptide FLWGKSY showed the best anti-inflammatory activity in vitro.•Peptides derived from hen muscle can be used for anti-inflammatory applications. Spent hens have low market value and incur significant costs for disposal. This study explored the use of spent hens as a source of bioactive peptides. Spent hen hydrolysates prepared by Protease M or Protex 50FP exhibited interleukin (IL)-6 inhibitory activity in endotoxin-activated macrophage-like U937 cells (p 
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2018.01.093