A high level of high-density lipoprotein cholesterol is a protective factor against transplant renal artery stenosis

To investigate the factors associated with the occurrence of transplant renal artery stenosis (TRAS). A retrospective analysis was conducted in 26 recipients who developed TRAS and 40 concurrent renal recipients without TRAS. We also conducted a nested case-control study in 14 patients with TRAS (TR...

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Published in:Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2018-02, Vol.38 (2), p.155-161
Main Authors: Liu, Yan-Na, Yu, Li-Xin, Deng, Wen-Feng, Li, Kai-Qun, Liu, Ru-Min, Ye, Gui-Rong, Fu, Fang-Xiang, Li, Jiang-Tao, Miao, Yun
Format: Article
Language:Chinese
Subjects:
Case-Control Studies
Cholesterol, HDL - blood
Graft Rejection - physiopathology
Humans
Kidney Transplantation - adverse effects
Protective Factors
Renal Artery Obstruction - physiopathology
Retrospective Studies
Treatment Outcome
Warm Ischemia
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Summary:To investigate the factors associated with the occurrence of transplant renal artery stenosis (TRAS). A retrospective analysis was conducted in 26 recipients who developed TRAS and 40 concurrent renal recipients without TRAS. We also conducted a nested case-control study in 14 patients with TRAS (TRAS-SD group) and another 14 non-TRAS recipients who received the allograft from the same donor (non-TRAS-SD group). Compared with those in the concurrent recipients without TRAS, acute rejection (AR) occurred at a significantly higher incidence (P=0.004) and the warm ischemia time (WIT) was significantly longer (P=0.015) and the level of high?density lipoprotein cholesterol (HDL--C) significantly lower (P=0.009) in the recipients with TRAS. Logistic regression analysis suggested that AR (P=0.007) and prolonged WIT (P=0.046) were risk factors of TRAS while HDL-C (P=0.022) was the protective factor against TRAS. In recent years early diagnosis of TRAS had been made in increasing cases, the interval from transplantati
ISSN:1673-4254