Comparison of 3 He and 129 Xe MRI for evaluation of lung microstructure and ventilation at 1.5T

To support translational lung MRI research with hyperpolarized Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of Xe f...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2018-03, Vol.48 (3), p.632-642
Main Authors: Stewart, Neil J, Chan, Ho-Fung, Hughes, Paul J C, Horn, Felix C, Norquay, Graham, Rao, Madhwesha, Yates, Denise P, Ireland, Rob H, Hatton, Matthew Q, Tahir, Bilal A, Ford, Paul, Swift, Andrew J, Lawson, Rod, Marshall, Helen, Collier, Guilhem J, Wild, Jim M
Format: Article
Language:English
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Summary:To support translational lung MRI research with hyperpolarized Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of Xe functional metrics have not been reported. To compare hyperpolarized Xe and He MRI-derived quantitative metrics of lung ventilation and microstructure, and their repeatability, at 1.5T. Retrospective. Fourteen healthy nonsmokers (HN), five exsmokers (ES), five patients with chronic obstructive pulmonary disease (COPD), and 16 patients with nonsmall-cell lung cancer (NSCLC). 1.5T. NSCLC, COPD patients and selected HN subjects underwent 3D balanced steady-state free-precession lung ventilation MRI using both He and Xe. Selected HN, all ES, and COPD patients underwent 2D multislice spoiled gradient-echo diffusion-weighted lung MRI using both hyperpolarized gas nuclei. Ventilated volume percentages (VV%) and mean apparent diffusion coefficients (ADC) were derived from imaging. COPD patients performed the whole MR protocol in four separate scan sessions to assess repeatability. Same-day pulmonary function tests were performed. Intermetric correlations: Spearman's coefficient. Intergroup/internuclei differences: analysis of variance / Wilcoxon's signed rank. Repeatability: coefficient of variation (CV), intraclass correlation (ICC) coefficient. A significant positive correlation between He and Xe VV% was observed (r = 0.860, P 
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.25992