Sesbania gum based hydrogel as platform for sustained drug delivery: An ‘in vitro’ study of 5-Fu release

• Published in: International journal of biological macromolecules 2018-07, Vol.113, p.1116-1124
• Main Authors: Pal, Pinki, Pandey, Jay Prakash, Sen, Gautam
• Format: Article
• Language: English
• Subjects: 5-Fluorouracil; Croslinked copolymer; Sustained drug delivery
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2018.02.143

The purpose of this study is to fabricate 5-Fluorouracil sustained release matrix based on a novel, nontoxic, eco-friendly modified biopolymer. The sesbania gum based hydrogel has been prepared by microwave assisted method using acrylamide as a monomer and N,N Methylenebisacrylamide as a crosslinker. The crosslink copolymerization has been confirmed by several modern techniques such as FTIR, SEM, XRD, TGA, DSC, elemental analysis etc. The bioactive 5-Fluorouracil has been encapsulated via solvent swelling method and its release rate has been investigated in various pH dissolution medium through USP standard protocol. The synthesized hydrogel with higher degree of crosslinking exhibited slower release rate than that of hydrogel having lower degree of crosslinking. Thus, resulting higher t25 value, the release rate increases with increase in pH of the medium. Release kinetics suggests the non-Fickian release behaviour of the hydrogel. [Display omitted] •Grafted-crosslinked sesbania gum studied as matrix for sustained release of 5-FU•The 5-FU encapsulated via solvent swelling method•Release rate studied in various pH dissolution medium by USP standard protocol•Diffusion mechanism was analyzed mathematically from release kinetics.•Preferred site of drug release in gastro-intestinal tract speculated based on pH