Prognostic importance of solid variant papillary thyroid carcinoma: A systematic review and meta‐analysis

Background Solid variant papillary thyroid carcinoma (SVPTC) is a rare variant of papillary thyroid cancer (PTC) and its prognostic value is still unclear. The purpose of this systematic clinical review and meta‐analysis is to investigate the prognostic value of SVPTC in comparison with classical PT...

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Bibliographic Details
Published in:Head & neck 2018-07, Vol.40 (7), p.1588-1597
Main Authors: Vuong, Huy Gia, Odate, Toru, Duong, Uyen N. P., Mochizuki, Kunio, Nakazawa, Tadao, Katoh, Ryohei, Kondo, Tetsuo
Format: Article
Language:English
Subjects:
aggressive variant
Disease-Free Survival
Female
Head and neck
Humans
Male
Meta-analysis
Mortality
Neoplasm Recurrence, Local
Papillary thyroid cancer
Papillary thyroid carcinoma
Prognosis
solid
solid variant
solid/trabecular
Thyroid cancer
Thyroid Cancer, Papillary - complications
Thyroid Cancer, Papillary - mortality
Thyroid Neoplasms - complications
Thyroid Neoplasms - mortality
trabecular
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Summary:Background Solid variant papillary thyroid carcinoma (SVPTC) is a rare variant of papillary thyroid cancer (PTC) and its prognostic value is still unclear. The purpose of this systematic clinical review and meta‐analysis is to investigate the prognostic value of SVPTC in comparison with classical PTC (cPTC). Methods Four electronic databases, including PubMed, Scopus, Web of Science, and Virtual Health Library, were searched in June 2017. Extracted data were pooled into odds ratio (OR) or hazard ratio (HR) and their corresponding 95% confidence interval (CI) using the random‐effect model. Results From 1439 articles, we finally included 11 studies with 205 SVPTCs for meta‐analysis. Overall, SVPTC manifested a significantly higher risk for vascular invasion, tumor recurrence, and cancer mortality as compared to cPTC. The genetic profile of SVPTC was also distinct from that of cPTC. Conclusion A case of SVPTC should be regarded as an aggressive variant of PTC because of a higher risk for tumor recurrence and mortality.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25123