Isavuconazole pharmacokinetics in a patient with cystic fibrosis following bilateral orthotopic lung transplantation

Previous studies of patients with cystic fibrosis (CF) treated with azole antifungals have shown altered pharmacokinetics relative to healthy patients. Data regarding the pharmacokinetic profile of isavuconazole in patients with CF undergoing lung transplantation are currently not available. Serum t...

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Bibliographic Details
Published in:Transplant infectious disease : an official journal of the Transplantation Society 2018, Vol.20 (3), p.e12878-e12878
Main Authors: Kabulski, Galen M, MacVane, Shawn H
Format: Report
Language:English
Online Access:Get full text
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Summary:Previous studies of patients with cystic fibrosis (CF) treated with azole antifungals have shown altered pharmacokinetics relative to healthy patients. Data regarding the pharmacokinetic profile of isavuconazole in patients with CF undergoing lung transplantation are currently not available. Serum trough concentrations assessed in a single CF patient following transplant revealed significantly lower values relative to available literature. Larger studies are required to validate CF population pharmacokinetics of isavuconazole.
ISSN:1399-3062
DOI:10.1111/tid.12878