Aggressive laryngeal fibromatosis: A case report and brief review

We describe a rare case of aggressive fibromatosis of the larynx occurring in a 72-year-old man. The lesion manifested with complaints of dyspnea and stridor. A computerized tomographic scan of the neck revealed irregular polypoidal growth invading right vocal cord, crossing midline. A malignant tum...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2018-01, Vol.14 (2), p.465-467
Main Authors: Khan, Enam, Sutradhar, Arpita, Bandopadhay, Sougata
Format: Article
Language:English
Subjects:
Abdomen
Adults
Aged
Biomarkers
Biopsy
Case reports
Case studies
CAT scans
Collagen
Diagnosis
Fibroma
Fibromatosis, Aggressive - diagnosis
Fibromatosis, Aggressive - therapy
Health aspects
Humans
Immunohistochemistry
Laryngeal Neoplasms - diagnosis
Laryngeal Neoplasms - therapy
Laryngectomy
Larynx
Male
Medical prognosis
Neck
Ostomy
Otolaryngology
Pathology
Surgery
Tomography, X-Ray Computed
Treatment Outcome
Tumors
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Summary:We describe a rare case of aggressive fibromatosis of the larynx occurring in a 72-year-old man. The lesion manifested with complaints of dyspnea and stridor. A computerized tomographic scan of the neck revealed irregular polypoidal growth invading right vocal cord, crossing midline. A malignant tumor was suspected. Although several laryngoscopy-driven biopsies were negative for malignancy, total laryngectomy was done since the lesion was not deemed amenable to conservative therapy. Tissue sections featured a moderately cellular lesion composed of spindle cells with bland, elongated nuclei, enmeshed in a variably collagenized ground substance. The spindle cells were immunopositive for vimentin and negative for cytokeratins, PGP-9.5, smooth muscle antigen, CD68, desmin, and S-100 protein and Ki-67 of 4%. No further therapy was administered. Based on the available literature, our data confirm that aggressive laryngeal fibromatosis in adult patients is a locally infiltrating disease. Total laryngectomy with clear margins is needed as to avoid the high risk of local recurrence.
ISSN:0973-1482
1998-4138
DOI:10.4103/0973-1482.183554