One-pot synthesis of diverse N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines via N-phthaloyl-guanidines

A sequential one-pot approach towards N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This pr...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2018-03, Vol.16 (12), p.2143-2149
Main Authors: Demjén, András, Angyal, Anikó, Wölfling, János, Puskás, László G, Kanizsai, Iván
Format: Article
Language:English
Subjects:
Amines
Guanidines
Substrates
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Summary:A sequential one-pot approach towards N,N'-disubstituted guanidines from N-chlorophthalimide, isocyanides and amines is reported. This strategy provides straightforward and efficient access to diverse guanidines in yields up to 81% through previously unprecedented N-phthaloylguanidines. This protocol also features wide substrate scope and mild conditions.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob03109b