Soft tissue metastasis of mediastinal non-functioning paraganglioma with unusual TTF-1 expression: a potential diagnostic pitfall

Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely th...

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Bibliographic Details
Published in:Polish journal of pathology 2017, Vol.68 (4), p.354-358
Main Authors: Benej, Michal, Zambo, Iva, Bílek, Ondrej, Capov, Ivan
Format: Article
Language:English
Subjects:
Abdomen
Catecholamines
Chemotherapy
Cytokeratin
Hypertension
Melanoma
Metastasis
Neuroendocrine tumors
Ostomy
Pain
Patients
Scintigraphy
Skin cancer
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Summary:Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary.
ISSN:1233-9687
2084-9869
DOI:10.5114/pjp.2017.73931