Synthesis and the Antiinflammatory Activity of New N-Acyl-5-Bromanthranilamides

Nineteen N-acyl-5-bromanthranilic acid amides were synthesized via acylation of 5-bromanthranilamide with suitable anhydrides. The antimicrobial activity of the synthesized compounds with respect to Staphylococcus aureus and Escherichia coli was evaluated. Compounds with diphenyl, furoyl, and tetrac...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal 2005-01, Vol.39 (1), p.15-17
Main Authors: Dolzhenko-Podchezertseva, A. V., Novikova, V. V., Korkodinova, L. M., Odegova, T. F.
Format: Article
Language:English
Subjects:
Escherichia coli
Staphylococcus aureus
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nineteen N-acyl-5-bromanthranilic acid amides were synthesized via acylation of 5-bromanthranilamide with suitable anhydrides. The antimicrobial activity of the synthesized compounds with respect to Staphylococcus aureus and Escherichia coli was evaluated. Compounds with diphenyl, furoyl, and tetrachlorophthalyl moieties in the acyl part of the molecule showed significant inhibition of microbial growth. The minimum inhibiting concentrations of this compounds were 15.6 mu g/ml against S. aureus and 15.6 - 31 mu g/ml against E. coli. Other tested amides were considerably less active.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-005-0070-7