Hemodynamic vascular biomarkers for initiation of paraclinoid internal carotid artery aneurysms using patient-specific computational fluid dynamic simulation based on magnetic resonance imaging

• Published in: Neuroradiology 2018-05, Vol.60 (5), p.545-555
• Main Authors: Watanabe, Tomoya, Isoda, Haruo, Takehara, Yasuo, Terada, Masaki, Naito, Takehiro, Kosugi, Takafumi, Onishi, Yuki, Tanoi, Chiharu, Izumi, Takashi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Aneurysm; Aneurysms; Angiography; Biomarkers; Biomarkers - blood; Carotid arteries; Carotid artery; Carotid Artery, Internal; Computational fluid dynamics; Computer applications; Computer simulation; Female; Fluid dynamics; Hemorheology; Humans; Hydrodynamics; Imaging; Imaging, Three-Dimensional; Interventional Neuroradiology; Intracranial Aneurysm - diagnostic imaging; Intracranial Aneurysm - physiopathology; Lesions; Magnetic Resonance Angiography; Magnetic resonance imaging; Magnetic Resonance Imaging, Cine; Male; Medicine; Medicine & Public Health; Middle Aged; Neurology; Neuroradiology; Neurosciences; Neurosurgery; NMR; Nuclear magnetic resonance; Patients; Radiology; Shear stress; Spatial distribution; Wall shear stresses
• ISSN: 0028-3940; 1432-1920
• DOI: 10.1007/s00234-018-2002-8

Purpose We performed computational fluid dynamics (CFD) for patients with and without paraclinoid internal carotid artery (ICA) aneurysms to evaluate the distribution of vascular biomarkers at the aneurysm initiation sites of the paraclinoid ICA. Methods This study included 35 patients who were followed up for aneurysms using 3D time of flight (TOF) magnetic resonance angiography (MRA) and 3D cine phase-contrast MR imaging. Fifteen affected ICAs were included in group A with the 15 unaffected contralateral ICAs in group B. Thirty-three out of 40 paraclinoid ICAs free of aneurysms and arteriosclerotic lesions were included in group C. We deleted the aneurysms in group A based on the 3D TOF MRA dataset. We performed CFD based on MR data set and obtained wall shear stress (WSS), its derivatives, and streamlines. We qualitatively evaluated their distributions at and near the intracranial aneurysm initiation site among three groups. We also calculated and compared the normalized highest (nh-) WSS and nh-spatial WSS gradient (SWSSG) around the paraclinoid ICA among three groups. Results High WSS and SWSSG distribution were observed at and near the aneurysm initiation site in group A. High WSS and SWSSG were also observed at similar locations in group B and group C. However, nh-WSS and nh-SWSSG were significantly higher in group A than in group C, and nh-SWSSG was significantly higher in group A than in group B. Conclusion Our findings indicated that nh-WSS and nh-SWSSG were good biomarkers for aneurysm initiation in the paraclinoid ICA.