TG/HDL-C ratio and visceral adiposity index may be useful in assessment of insulin resistance in adults with type 1 diabetes in clinical practice

• Published in: Journal of clinical lipidology 2018-05, Vol.12 (3), p.734-740
• Main Authors: Uruska, Aleksandra, Zozulinska-Ziolkiewicz, Dorota, Niedzwiecki, Pawel, Pietrzak, Monika, Wierusz-Wysocka, Bogna
• Format: Article
• Language: English
• Subjects: Diabetes mellitus type 1; Glucose disposal rate; Hyperinsulinemic-euglycemic clamp; Insulin resistance; TG/HDL-C ratio; Visceral adiposity index
• ISSN: 1933-2874; 1876-4789
• DOI: 10.1016/j.jacl.2018.01.005

Insulin resistance (IR) is an important clinical issue in patients with type 1 diabetes due to worse metabolic control and risk of development of chronic complications. The aim of the study was to evaluate simple and easily available parameters as indirect markers of IR in adults with type 1 diabetes and correlate it with the results of hyperinsulinemic-euglycemic clamp. The study included 88 patients (62 men), aged 34.1 ± 6.5 years, with type 1 diabetes with a median disease duration of 8 (7–13) years and mean HbA1c of 7.6 ± 1.5%. Tissue sensitivity to insulin was assessed on the basis of glucose distribution rate (GDR) obtained in the course of hyperinsulinemic-euglycemic clamp. In addition, indirect markers of IR, such as estimated GDR, presence of features of metabolic syndrome, visceral adiposity index (VAI), and the triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, were evaluated. In the study group, IR defined as GDR