Assessment of the antibiofilm and antiquorum sensing activities of Eucalyptus globulus essential oil and its main component 1,8-cineole against methicillin-resistant Staphylococcus aureus strains

Antibacterial resistance is an increasingly serious threat to global public health. The search for new anti-infection agents from natural resources, with different mode of actions and competitive effects became a necessity. In this study, twenty height methicillin-resistant Staphylococcus aureus (MR...

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Bibliographic Details
Published in:Microbial pathogenesis 2018-05, Vol.118, p.74-80
Main Authors: Merghni, Abderrahmen, Noumi, Emira, Hadded, Ons, Dridi, Neyla, Panwar, Harsh, Ceylan, Ozgur, Mastouri, Maha, Snoussi, Mejdi
Format: Article
Language:English
Subjects:
1,8-Cineole
Antibacterial
Antiquorum sensing
Biofilm
Eucalyptus globulus
MRSA
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Summary:Antibacterial resistance is an increasingly serious threat to global public health. The search for new anti-infection agents from natural resources, with different mode of actions and competitive effects became a necessity. In this study, twenty height methicillin-resistant Staphylococcus aureus (MRSA) strains were investigated for their biofilm formation ability. Subsequently, the antibiofilm effects of Eucalyptus globulus essential oil and its main component 1,8-cineole, against MRSA, as well as their antiquorum sensing potential, were evaluated. Our results displayed the potent efficacy of both E. globulus essential oil and 1,8-cineole against the development of biofilms formed by the methicillin-resistant strains. Additionally, E. globulus essential oil showed more potent of anti-QS activity, even at a low concentration, when compared to 1,8-cineole. All these property of tested agents may pave the way to prevent the development of biofilm formation by MRSA and subsequently the spreading of nosocomial infection. •Methicillin-resistant Staphylococcus aureus (MRSA) strains were investigated for their biofilm formation ability.•Antibacterial properties of the E. globulus EO and the 1,8-cineole, were investigated against characterized MRSA strains.•Tested agents showed an interesting antibacterial, antibiofilm, anti-swarming and anti-quorum sensing activities.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2018.03.006