High intensity exercise preconditioning provides differential protection against brain injury following experimental stroke

Different modes of physical activity provide cerebrovascular protection against thromboembolic events. Based on recent reports high intensity exercise protocols appear to raise cerebral VEGF levels leading to efficient cerebral angiogenesis. The present study aims to address if moderate continuous t...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2018-08, Vol.207, p.30-35
Main Authors: Rezaei, Rasoul, Nasoohi, Sanaz, Haghparast, Abbas, Khodagholi, Fariba, Bigdeli, Mohammad Reza, Nourshahi, Maryam
Format: Article
Language:English
Subjects:
Angiogenesis
Exercise
Exercise preconditioning
Experiments
Head injuries
Ischemic stroke
Occlusion
Preconditioning
Stroke
Training
Traumatic brain injury
VEGF signaling
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Different modes of physical activity provide cerebrovascular protection against thromboembolic events. Based on recent reports high intensity exercise protocols appear to raise cerebral VEGF levels leading to efficient cerebral angiogenesis. The present study aims to address if moderate continuous training (MCT) and high intensity interval training (HIT) differ in preconditioning against ischemic stroke. Wistar rats were subjected to HIT or MCT for 8 weeks before transient middle cerebral artery occlusion (tMCAO) surgery. As indexes for improved angiogenic signals, VEGF-A and its pivotal receptor VEGF-R2 were immunoblotted just before occlusive stroke. Both training protocols induced a remarkable protection against neurological deficit and tissue injury following stroke. Cerebral infarctions were better improved in HIT animals which explained the slightly but not significantly higher neurological function. HIT brains developed higher levels of cortical VEGF-A and striatal VEGF-R2. These data conclude preconditioning with high intensity protocols might excel continued moderate exercise to induce VEGF signaling and alleviate stroke outcomes. Further investigations may provide complementary mechanistic views.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2018.03.007