Do checkpoint inhibitors provide new hope for management of metastatic penile carcinoma?

[...]checkpoint inhibitors showed interesting results in virus-induced cancer, namely those related to HPV in SCC of the head and neck, the cervix and the anus (16). [...]these tumors had a similar histologic (squamous cell tumors), epidemiologic (viral-induced tumors) and therapeutic (platinum and...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2018-04, Vol.14 (8), p.677-680
Main Authors: Eid, Roland, Nemr, Elie, Haddad, Fady GH, Kourie, Hampig Raphael, Kattan, Joseph
Format: Article
Language:English
Subjects:
B7-H1 Antigen - antagonists & inhibitors
B7-H1 Antigen - genetics
Cancer therapies
Carcinoma - drug therapy
Carcinoma - epidemiology
Carcinoma - genetics
Carcinoma - pathology
checkpoint inhibitors
Chemotherapy
Circumcision
Genital cancers
Human papillomavirus
Humans
Lymphatic system
Male
Metastasis
metastatic
Monoclonal antibodies
Neoplasm Metastasis
ongoing trials
PD-L1
penile carcinoma
Penile Neoplasms - drug therapy
Penile Neoplasms - epidemiology
Penile Neoplasms - genetics
Penile Neoplasms - pathology
Penis
preliminary results
Radiation therapy
rare cancers
rationale
Risk Factors
standard therapy
Surgery
Targeted cancer therapy
treatment
Tsunamis
Tumors
Urology
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Description
Summary:[...]checkpoint inhibitors showed interesting results in virus-induced cancer, namely those related to HPV in SCC of the head and neck, the cervix and the anus (16). [...]these tumors had a similar histologic (squamous cell tumors), epidemiologic (viral-induced tumors) and therapeutic (platinum and anti-EGFR agents sensitive) background, probably leading to the same possible benefits from these agents in this indication. [...]in fit patients with an objective response to systemic chemotherapy, surgical consolidation (e.g.,inguinal lymph node dissection) with curative potential or palliation should be considered (12). [...]postoperative radiotherapy can be offered depending on the amount of residual disease after chemotherapy (25). [...]a Phase II trial of 334patients is evaluating the combination of nivolumab and ipilimumab in advanced rare cancers, including advanced squamous penile carcinoma (NCT02834013).
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2017-0559