Antibiotics‐induced modulation of large intestinal microbiota altered aromatic amino acid profile and expression of neurotransmitters in the hypothalamus of piglets

The evidence of gut microbiota‐mediated modulation of brain function has been widely recognized from studies using germ‐free rodents or animals with oral antibiotic‐induced microbiota depletion. Since the large intestine harbors greater numbers and more diverse of microbes than in the small intestin...

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Bibliographic Details
Published in:Journal of neurochemistry 2018-08, Vol.146 (3), p.219-234
Main Authors: Gao, Kan, Pi, Yu, Mu, Chun‐Long, Peng, Yu, Huang, Zan, Zhu, Wei‐Yun
Format: Article
Language:English
Subjects:
Amino acid composition
Amino acids
Antibiotics
aromatic amino acids
Blood
Brain
Composition
Dopamine
Fecal microflora
Gene expression
Hypothalamus
Ileum
Intestinal microflora
Large intestine
Medical materials
Metabolism
Microbiota
Microorganisms
Modulation
neurotransmitter
Neurotransmitters
Rodents
Small intestine
Tubes
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Summary:The evidence of gut microbiota‐mediated modulation of brain function has been widely recognized from studies using germ‐free rodents or animals with oral antibiotic‐induced microbiota depletion. Since the large intestine harbors greater numbers and more diverse of microbes than in the small intestine, large intestinal microbiota may play a crucial role in the modulation of brain function. In this study, a large intestinal microbiota‐targeted strategy was used to investigate the impact of large intestinal microbiota on brain function. Twelve piglets (12.08 ± 0.28 kg) fitted with a T‐cannula at the distal ileum were fed a standard diet and randomly assigned to two groups (n = 6) for ileal infusion of either saline or antibiotics. After 25 days of infusion, ileal and fecal microbiota, serum amino acids and neurotransmitters, and hypothalamic transcriptomics were analyzed. While the antibiotic infusion did not change the proximal ileal microbial composition, it markedly altered the fecal microbial composition and increased aromatic amino acid (AAAs) metabolism (p 
ISSN:0022-3042
1471-4159
DOI:10.1111/jnc.14333