Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor α − 1 expression

• Published in: Phytomedicine (Stuttgart) 2018-03, Vol.41, p.67-73
• Main Authors: Jafari, Nesa, Nazeri, Sonbol, Enferadi, Sattar Tahmasebi
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis; Apoptosis - drug effects; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cell Death - drug effects; Female; Humans; MCF-7 Cells; Metastasis; Parthenolide; Peptide Elongation Factor 1 - antagonists & inhibitors; Peptide Elongation Factor 1 - metabolism; Sesquiterpenes - pharmacology; Tanacetum parthenium - chemistry; Vimentin - antagonists & inhibitors; Vimentin - metabolism; Vimentin and Elongation factor α − 1
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1016/j.phymed.2018.01.022

Use of pharmaceutical agent for breast cancer chemotherapy is an interesting method that induces cells death by different way, such as apoptosis. Parthenolide is the main compound in feverfew that has been used to cure migraine and rheumatoid arthritis for long time. Parthenolide has been predominately investigated as inducer of apoptosis in human cancer cells. Purpose: We examined the expression of vimentin and Elongation factor α − 1 as breast cancer biomarkers in MCF7 cells exposure to Parthenolide. In this study, we investigated the antitumor mechanism of Parthenolide on the human breast cancer cell line MCF7, using SEM, flow cytometry and proteomics techniques. Comparative proteome analyses are shown Elongation factor1-α and vimentin was suppressed in response to Parthenolide treatment. [Display omitted]