Combined human papillomavirus typing and TP53 mutation analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma

Background In head and neck squamous cell carcinoma (HNSCC), the occurrence of concurrent lung malignancies poses a significant diagnostic challenge because metastatic HNSCC is difficult to discern from second primary lung squamous cell carcinoma (SCC). However, this differentiation is crucial becau...

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Bibliographic Details
Published in:Head & neck 2018-06, Vol.40 (6), p.1109-1119
Main Authors: Daher, Tamas, Tur, Mehmet Kemal, Brobeil, Alexander, Etschmann, Benjamin, Witte, Biruta, Engenhart‐Cabillic, Rita, Krombach, Gabriele, Blau, Wolfgang, Grimminger, Friedrich, Seeger, Werner, Klussmann, Jens Peter, Bräuninger, Andreas, Gattenlöhner, Stefan
Format: Article
Language:English
Subjects:
Exons
Head & neck cancer
head and neck cancer metastasis
Human papillomavirus
human papillomavirus (HPV)
Lung cancer
Lung carcinoma
Metastases
Metastasis
Mutation
next generation sequencing
p53
p53 Protein
Patients
Squamous cell carcinoma
Tumors
Typing
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Summary:Background In head and neck squamous cell carcinoma (HNSCC), the occurrence of concurrent lung malignancies poses a significant diagnostic challenge because metastatic HNSCC is difficult to discern from second primary lung squamous cell carcinoma (SCC). However, this differentiation is crucial because the recommended treatments for metastatic HNSCC and second primary lung SCC differ profoundly. Methods We analyzed the origin of lung tumors in 32 patients with HNSCC using human papillomavirus (HPV) typing and targeted next generation sequencing of all coding exons of tumor protein 53 (TP53). Results Lung tumors were clearly identified as HNSCC metastases or second primary tumors in 29 patients, thus revealing that 16 patients had received incorrect diagnoses based on clinical and morphological data alone. Conclusion The HPV typing and mutation analysis of all TP53 coding exons is a valuable diagnostic tool in patients with HNSCC and concurrent lung SCC, which can help to ensure that patients receive the most suitable treatment.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25041