Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese

We aimed to investigate the association of 12 extensively studied polymorphisms in adiponectin (ADIPOQ), adiponectin receptor-1 (ADIPOR1) and adiponectin receptor-2 (ADIPOR2) genes with myocardial infarction in Han Chinese. This is a hospital-based, cross-sectional, case-control study, including 717...

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Bibliographic Details
Published in:Gene 2018-06, Vol.658, p.10-17
Main Authors: Zhang, Zhiyong, Li, Yingxue, Yang, Xinchun, Wang, Lefeng, Xu, Li, Zhang, Qi
Format: Article
Language:English
Subjects:
Adiponectin
Association
Myocardial infarction
Nomogram
Risk
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Summary:We aimed to investigate the association of 12 extensively studied polymorphisms in adiponectin (ADIPOQ), adiponectin receptor-1 (ADIPOR1) and adiponectin receptor-2 (ADIPOR2) genes with myocardial infarction in Han Chinese. This is a hospital-based, cross-sectional, case-control study, including 717 myocardial infarction patients and 612 controls. Myocardial infarction was confirmed through electrocardiogram/anatomopathological examinations. All polymorphisms met the Hardy-Weinberg equilibrium (p > 0.05). The genotype/allele counts of ADIPOQ gene rs2241766 (p = 0.001/0.003) and ADIPOR2 gene rs10773989 (p 
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2018.03.022