How should incidental NEN of the pancreas and gastrointestinal tract be followed?

Neuroendocrine gastro-entero-pancreatic neoplasms (GEP-NENs) constitute a heterogeneous group of tumors, whose incidence has increased over the years. The most frequent site for primary disease is the stomach followed by small and large intestine, and pancreas. In the last decade, a dramatic growing...

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Bibliographic Details
Published in:Reviews in endocrine & metabolic disorders 2018-06, Vol.19 (2), p.139-144
Main Authors: Ariotti, Riccardo, Partelli, Stefano, Muffatti, Francesca, Andreasi, Valentina, Della Sala, Francesca, Falconi, Massimo
Format: Article
Language:English
Subjects:
Diabetes
Endocrinology
Gastrointestinal tract
Internal Medicine
Large intestine
Medicine
Medicine & Public Health
Pancreas
Pancreatic cancer
Stomach
Surveillance
Tumors
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Summary:Neuroendocrine gastro-entero-pancreatic neoplasms (GEP-NENs) constitute a heterogeneous group of tumors, whose incidence has increased over the years. The most frequent site for primary disease is the stomach followed by small and large intestine, and pancreas. In the last decade, a dramatic growing in the incidence of small, incidental GEP-NENs has been recorded. In parallel, an increasing attitude toward more conservative approaches instead of surgical management has being widely spreading. This is particularly true for small, asymptomatic, pancreatic NEN as for these tumor forms an active surveillance has proven to be safe and feasible. Primary site and biological features of the neoplasms lead to different strategies and indications for surveillance and follow-up. This review focuses on the current evidence on modality and timing of surveillance and conservative treatment of incidentally discovered lesions.
ISSN:1389-9155
1573-2606
DOI:10.1007/s11154-018-9445-4