Molecular recognition by synthetic receptors: Application in field-effect transistor based chemosensing

Molecular recognition, i.e., ability of one molecule to recognize another through weak bonding interactions, is one of the bases of life. It is often implemented to sensing systems of high merits. Preferential recognition of the analyte (guest) by the receptor (host) induces changes in physicochemic...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2018-06, Vol.109, p.50-62
Main Authors: Iskierko, Zofia, Noworyta, Krzysztof, Sharma, Piyush Sindhu
Format: Article
Language:English
Subjects:
Biosensing Techniques
Electrical transduction
Extended-gate field-effect transistor
Field-effect transistor
Humans
Molecularly imprinted polymer
Receptors, Artificial - chemistry
Synthetic receptor
Transistors, Electronic
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Summary:Molecular recognition, i.e., ability of one molecule to recognize another through weak bonding interactions, is one of the bases of life. It is often implemented to sensing systems of high merits. Preferential recognition of the analyte (guest) by the receptor (host) induces changes in physicochemical properties of the sensing system. These changes are measured by using suitable signal transducers. Because of possibility of miniaturization, fast response, and high sensitivity, field-effect transistors (FETs) are more frequently being used for that purpose. A FET combined with a biological material offers the potential to overcome many challenges approached in sensing. However, low stability of biological materials under measurement conditions is a serious problem. To circumvent this problem, synthetic receptors were integrated with the gate surface of FETs to provide robust performance. In the present critical review, the approach utilized to devise chemosensors integrating synthetic receptors and FET transduction is discussed in detail. The progress in this field was summarized and important outcome was provided. [Display omitted] •The approaches utilized to integrate synthetic receptors and FETs are reviewed.•Synthetic receptors can provide the desired selectivity to FETs.•The EG-FETs integrated with synthetic recognition films have wider applications.•Importance of minimizing or overcoming ionic screening effects is stressed.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2018.02.058