The gut microbiota and its potential role in obesity

The human GI tract harbors a diverse and dynamic microbial community comprising bacteria, archaea, viruses and eukaryotic microbes, which varies in composition from individual to individual. A healthy microbiota metabolizes various indigestible dietary components of the host, maintains host immune h...

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Bibliographic Details
Published in:Future microbiology 2018-04, Vol.13 (5), p.589-603
Main Authors: Shabana, Shahid, Saleem U, Irfan, Uzma
Format: Article
Language:English
Subjects:
Animals
Babies
Bacteria
Body Weight
Breastfeeding & lactation
Cesarean section
Diet
Environment
Feces
Food
Gastrointestinal Microbiome
Gastrointestinal tract
Gastrointestinal Tract - microbiology
Gene expression
Homeostasis
Humans
Intestinal microflora
Metabolism
Metabolomics
Mice
Mice, Knockout
Microbiota
Microorganisms
Models, Animal
Obesity
Obesity - microbiology
Oils & fats
Rats
rodent
Socioeconomic Factors
Viruses
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Summary:The human GI tract harbors a diverse and dynamic microbial community comprising bacteria, archaea, viruses and eukaryotic microbes, which varies in composition from individual to individual. A healthy microbiota metabolizes various indigestible dietary components of the host, maintains host immune homeostasis and nutrient intake, but, an imbalanced microbiota has been reported to be associated with many diseases, including obesity. Rodent studies have produced evidence in support of the causal role of the gut microbiota in the development of obesity, however, such causal relationship is lacking in humans. The objective of this review is to critically analyze the vast information available on the composition, function and alterations of the gut microbiota in obesity and explore the future prospects of this research area.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2017-0179