Depression and risk of fracture and bone loss: an updated meta-analysis of prospective studies

Summary This meta-analysis pooled results from 23 qualifying individual cohort studies and found that depression was significantly associated with an increased risk of fractures and bone loss. Introduction The association between depression and risk of fracture remains controversial. We conducted a...

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Bibliographic Details
Published in:Osteoporosis international 2018-06, Vol.29 (6), p.1303-1312
Main Authors: Wu, Q., Liu, B., Tonmoy, S.
Format: Article
Language:English
Subjects:
Bone loss
Bone mineral density
Endocrinology
Fractures
Hip
Medicine
Medicine & Public Health
Mental depression
Meta-analysis
Original Article
Orthopedics
Osteoporosis
Rheumatology
Statistical analysis
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Summary:Summary This meta-analysis pooled results from 23 qualifying individual cohort studies and found that depression was significantly associated with an increased risk of fractures and bone loss. Introduction The association between depression and risk of fracture remains controversial. We conducted a comprehensive meta-analysis to examine the effect of depression on the risk of osteoporotic fractures and bone loss. Methods We searched databases and reviewed citations in relevant articles for eligible cohort studies. Two investigators independently conducted study selection, appraisal, and data abstraction through the use of a standardized protocol. Random effect models were used for meta-analysis. Cochrane Q and I 2 statistics were used to assess heterogeneity. Funnel plots and rank correlation tests were used to evaluate publication bias. Results Twenty-three studies were included for meta-analysis. In studies that reported hazard ratio (HR) as the outcome (nine studies [ n  = 309,862]), depression was associated with 26% increase in fracture risk (HR = 1.26, 95% CI, 1.10–1.43, p  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-018-4420-1