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Antimutagenic properties of a polyphenol-enriched extract derived from sesame-seed perisperm
A polyphenolic mixture derived from sesame-seed perisperm (SSP) strongly reduced the mutagenicity of hydrogen peroxide (H 2O 2), sodium azide (NaN 3), and benzo[a]pyrene (BaP) in strains TA100 and/or TA98 of Salmonella typhimurium. It exhibited desmutagenic activity against H 2O 2, BaP in TA98 and/o...
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| Published in: | Mutation research. Genetic toxicology and environmental mutagenesis 2007-12, Vol.634 (1), p.163-171 |
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| Main Authors: | , , |
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| container_end_page | 171 |
| container_issue | 1 |
| container_start_page | 163 |
| container_title | Mutation research. Genetic toxicology and environmental mutagenesis |
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| creator | Lazarou, Despoina Grougnet, Raphael Papadopoulos, Athanasios |
| description | A polyphenolic mixture derived from sesame-seed perisperm (SSP) strongly reduced the mutagenicity of hydrogen peroxide (H
2O
2), sodium azide (NaN
3), and benzo[a]pyrene (BaP) in strains TA100 and/or TA98 of
Salmonella typhimurium. It exhibited desmutagenic activity against H
2O
2, BaP in TA98 and/or TA100 and biomutagenic activity (apparently by affecting the DNA-repair system) against NaN
3 in strain TA100. According to
in vitro experiments the polyphenolic mixture inhibited the activity of the CYP1A1 (EROD) enzyme responsible for the activation of BaP in the Ames’ test, as well as that of the cytosolic enzyme GST.
A cytosolic fraction from liver of male Wistar rats treated with either 20% SSP in the food, or 3
mg or 6
mg of polyphenolic mixture/20
g food/day for a time period of 8 weeks reduced the mutagenic potential of BaP in strains TA100 and TA98, with the cytosolic fraction from rats treated with SSP causing the strongest reduction. Furthermore, a microsomal fraction from the 20% SSP-treated rats inhibited the mutagenicity of BaP in strains TA100 (26.3%) and TA98 (23%). In contrast, a microsomal fraction from rats treated with 3
mg of polyphenolic mixture stimulated the mutagenicity of BaP in TA100 but reduced it in TA98, while for the microsomal fraction from rats treated with 6
mg of polyphenolic mixture, these effects on TA100 and TA98 were reversed. |
| doi_str_mv | 10.1016/j.mrgentox.2007.07.008 |
| format | article |
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2O
2), sodium azide (NaN
3), and benzo[a]pyrene (BaP) in strains TA100 and/or TA98 of
Salmonella typhimurium. It exhibited desmutagenic activity against H
2O
2, BaP in TA98 and/or TA100 and biomutagenic activity (apparently by affecting the DNA-repair system) against NaN
3 in strain TA100. According to
in vitro experiments the polyphenolic mixture inhibited the activity of the CYP1A1 (EROD) enzyme responsible for the activation of BaP in the Ames’ test, as well as that of the cytosolic enzyme GST.
A cytosolic fraction from liver of male Wistar rats treated with either 20% SSP in the food, or 3
mg or 6
mg of polyphenolic mixture/20
g food/day for a time period of 8 weeks reduced the mutagenic potential of BaP in strains TA100 and TA98, with the cytosolic fraction from rats treated with SSP causing the strongest reduction. Furthermore, a microsomal fraction from the 20% SSP-treated rats inhibited the mutagenicity of BaP in strains TA100 (26.3%) and TA98 (23%). In contrast, a microsomal fraction from rats treated with 3
mg of polyphenolic mixture stimulated the mutagenicity of BaP in TA100 but reduced it in TA98, while for the microsomal fraction from rats treated with 6
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2O
2), sodium azide (NaN
3), and benzo[a]pyrene (BaP) in strains TA100 and/or TA98 of
Salmonella typhimurium. It exhibited desmutagenic activity against H
2O
2, BaP in TA98 and/or TA100 and biomutagenic activity (apparently by affecting the DNA-repair system) against NaN
3 in strain TA100. According to
in vitro experiments the polyphenolic mixture inhibited the activity of the CYP1A1 (EROD) enzyme responsible for the activation of BaP in the Ames’ test, as well as that of the cytosolic enzyme GST.
A cytosolic fraction from liver of male Wistar rats treated with either 20% SSP in the food, or 3
mg or 6
mg of polyphenolic mixture/20
g food/day for a time period of 8 weeks reduced the mutagenic potential of BaP in strains TA100 and TA98, with the cytosolic fraction from rats treated with SSP causing the strongest reduction. Furthermore, a microsomal fraction from the 20% SSP-treated rats inhibited the mutagenicity of BaP in strains TA100 (26.3%) and TA98 (23%). In contrast, a microsomal fraction from rats treated with 3
mg of polyphenolic mixture stimulated the mutagenicity of BaP in TA100 but reduced it in TA98, while for the microsomal fraction from rats treated with 6
mg of polyphenolic mixture, these effects on TA100 and TA98 were reversed.</description><subject>Ames’ test</subject><subject>Antimutagenicity</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Medical sciences</subject><subject>Polyphenol extract</subject><subject>Salmonella typhimurium</subject><subject>Sesame-seed perisperm</subject><subject>Toxicology</subject><issn>1383-5718</issn><issn>1879-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFUE1LAzEQXUTBWv0Lshe9bZ1s0k1ys4hfUPCiNyFks7M2ZXezJqnYf29KKx6FR2YyvPcmeVl2SWBGgFQ361nvP3CI7ntWAvDZDiCOsgkRXBZ0Lsvj1FNBizkn4jQ7C2ENUAIFMcneF0O0_Sbq5GBNPno3oo8WQ-7aXOej67bjCgfXFTh4a1bY5PgdvTYxb9Dbr3RvvevzgEH3WARMg-RgQzr68-yk1V3Ai0OdZm8P9693T8Xy5fH5brEsDJVVLEqmZSsRWl4xaEjdGME5N8ToppSATEiodS0qoCgqVlJdM5EgGLaMEVrTaXa9903P_9xgiKq3wWDX6QHdJqgSCOWsmiditSca70Lw2KrR2177rSKgdmGqtfoNU-3CVDuASMKrwwYdjO5arwdjw59aUk44k4l3u-dh-u6XRa-CsTgYbKxHE1Xj7H-rfgAP7pBC</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Lazarou, Despoina</creator><creator>Grougnet, Raphael</creator><creator>Papadopoulos, Athanasios</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20071201</creationdate><title>Antimutagenic properties of a polyphenol-enriched extract derived from sesame-seed perisperm</title><author>Lazarou, Despoina ; Grougnet, Raphael ; Papadopoulos, Athanasios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-24a9f9e0f7640d1bdc8777c1cad290e4890bab8603e86423ab48b4884ef4413b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Ames’ test</topic><topic>Antimutagenicity</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Medical sciences</topic><topic>Polyphenol extract</topic><topic>Salmonella typhimurium</topic><topic>Sesame-seed perisperm</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lazarou, Despoina</creatorcontrib><creatorcontrib>Grougnet, Raphael</creatorcontrib><creatorcontrib>Papadopoulos, Athanasios</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Mutation research. Genetic toxicology and environmental mutagenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lazarou, Despoina</au><au>Grougnet, Raphael</au><au>Papadopoulos, Athanasios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimutagenic properties of a polyphenol-enriched extract derived from sesame-seed perisperm</atitle><jtitle>Mutation research. Genetic toxicology and environmental mutagenesis</jtitle><date>2007-12-01</date><risdate>2007</risdate><volume>634</volume><issue>1</issue><spage>163</spage><epage>171</epage><pages>163-171</pages><issn>1383-5718</issn><eissn>1879-3592</eissn><abstract>A polyphenolic mixture derived from sesame-seed perisperm (SSP) strongly reduced the mutagenicity of hydrogen peroxide (H
2O
2), sodium azide (NaN
3), and benzo[a]pyrene (BaP) in strains TA100 and/or TA98 of
Salmonella typhimurium. It exhibited desmutagenic activity against H
2O
2, BaP in TA98 and/or TA100 and biomutagenic activity (apparently by affecting the DNA-repair system) against NaN
3 in strain TA100. According to
in vitro experiments the polyphenolic mixture inhibited the activity of the CYP1A1 (EROD) enzyme responsible for the activation of BaP in the Ames’ test, as well as that of the cytosolic enzyme GST.
A cytosolic fraction from liver of male Wistar rats treated with either 20% SSP in the food, or 3
mg or 6
mg of polyphenolic mixture/20
g food/day for a time period of 8 weeks reduced the mutagenic potential of BaP in strains TA100 and TA98, with the cytosolic fraction from rats treated with SSP causing the strongest reduction. Furthermore, a microsomal fraction from the 20% SSP-treated rats inhibited the mutagenicity of BaP in strains TA100 (26.3%) and TA98 (23%). In contrast, a microsomal fraction from rats treated with 3
mg of polyphenolic mixture stimulated the mutagenicity of BaP in TA100 but reduced it in TA98, while for the microsomal fraction from rats treated with 6
mg of polyphenolic mixture, these effects on TA100 and TA98 were reversed.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.mrgentox.2007.07.008</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1383-5718 |
| ispartof | Mutation research. Genetic toxicology and environmental mutagenesis, 2007-12, Vol.634 (1), p.163-171 |
| issn | 1383-5718 1879-3592 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20137465 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Ames’ test Antimutagenicity Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Medical sciences Polyphenol extract Salmonella typhimurium Sesame-seed perisperm Toxicology |
| title | Antimutagenic properties of a polyphenol-enriched extract derived from sesame-seed perisperm |
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