Action of Iron Nitrosyl Complexes, NO Donors, on the Activity of Sarcoplasmic Reticulum Ca2+-ATPase and Cyclic Guanosine Monophosphate Phosphodiesterase

The effect of iron nitrosyl complexes, NO donors, of a general formula [Fe 2 (L) 2 (NO) 4 ] with functional sulfur-containing ligands (L-3-nitro-phenol-2-yl, 4-nitro-phenol-2-yl, or 1-methyl-tetrazol-5-yl) on the activity of sarcoplasmic reticulum Ca 2+ -ATPase and cyclic guanosine monophosphate pho...

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Published in:Doklady. Biochemistry and biophysics 2018, Vol.478 (1), p.8-13
Main Authors: Tat’yanenko, L. V., Sanina, N. A., Dobrokhotova, O. V., Kotelnikov, A. I., Goryachev, N. S., Pihteleva, I. I., Kozub, G. I., Kondrateva, T. A.
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Ca2+-transporting ATPase
Calcium (reticular)
Calcium transport
Capillaries
Cyclic GMP
Endothelium
Guanosine
Iron
Life Sciences
Metastases
Molecular Biology
Phenols
Phosphodiesterase
Sarcoplasmic reticulum
Sulfur
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Summary:The effect of iron nitrosyl complexes, NO donors, of a general formula [Fe 2 (L) 2 (NO) 4 ] with functional sulfur-containing ligands (L-3-nitro-phenol-2-yl, 4-nitro-phenol-2-yl, or 1-methyl-tetrazol-5-yl) on the activity of sarcoplasmic reticulum Ca 2+ -ATPase and cyclic guanosine monophosphate phosphodiesterase (cGMP PDE) was studied. The test complexes uncoupled the hydrolytic and transport functions of Ca 2+ - ATPase, thus disturbing the balance of Ca 2+ ions in cells, which may affect the formation of thrombi and adhesion of metastatic cells to the endothelium of capillaries. They also inhibited the activity of cGMP PDE, thereby contributing to the accumulation of the second messenger cGMP. The studied iron nitrosyl complexes can be considered as potential drugs.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672918010039