Evaluation of the Cepheid® Xpert®C. difficile binary toxin (BT) diagnostic assay

Strains of Clostridium difficile producing only binary toxin (CDT) are found commonly in animals but not humans. However, human diagnostic tests rarely look for CDT. The Cepheid Xpert C. difficile BT assay detects CDT with equal sensitivity (≥92%) in human and animal faecal samples. •Clostridium dif...

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Bibliographic Details
Published in:Anaerobe 2018-06, Vol.51, p.12-16
Main Authors: McGovern, Alan M., Androga, Grace O., Moono, Peter, Collins, Deirdre A., Foster, Niki F., Chang, Barbara J., Riley, Thomas V.
Format: Article
Language:English
Subjects:
Binary toxin
CDT
Clostridium difficile infection
Diagnostics
Piglets
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Summary:Strains of Clostridium difficile producing only binary toxin (CDT) are found commonly in animals but not humans. However, human diagnostic tests rarely look for CDT. The Cepheid Xpert C. difficile BT assay detects CDT with equal sensitivity (≥92%) in human and animal faecal samples. •Clostridium difficile binary toxin (CDT) is not detected by most diagnostic tests.•The Cepheid Xpert C. difficile BT assay reports CDT regardless of other toxins.•The assay is equally sensitive (≥92%) in both human and animal samples.
ISSN:1075-9964
1095-8274
DOI:10.1016/j.anaerobe.2018.03.004