Photo and Thermo Dual‐Responsive Copolymer Surfaces for Efficient Cell Capture and Release

To overcome the low efficiency of single‐responsive smart surfaces, we have constructed a dual‐responsive smart surface – poly(spiropyran‐co‐N‐isopropylacrylamide) (poly(SP‐co‐NiPAAm))‐grafted silicon nanowire arrays – by combining photo‐responsive SP and thermo‐responsive NiPAAm units for enhancing...

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Bibliographic Details
Published in:Chemphyschem 2018-08, Vol.19 (16), p.2107-2112
Main Authors: Hao, Yuwei, Liu, Hongliang, Li, Guannan, Cui, Haijun, Jiang, Lei, Wang, Shutao
Format: Article
Language:English
Subjects:
Biomedical materials
cell capture and release
Isomerization
Isopropylacrylamide
Nanowires
Phase transitions
Smart materials
smart surface
Steric hindrance
stimuli-responsive material
surface chemistry
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Summary:To overcome the low efficiency of single‐responsive smart surfaces, we have constructed a dual‐responsive smart surface – poly(spiropyran‐co‐N‐isopropylacrylamide) (poly(SP‐co‐NiPAAm))‐grafted silicon nanowire arrays – by combining photo‐responsive SP and thermo‐responsive NiPAAm units for enhancing the efficiencies of cancer‐cell capture and release. These enhanced efficiencies probably originate from the binary cooperative effect of two responsive building units: NiPAAm units can decrease the steric hindrance between SP units during the isomerization while SP units can facilitate phase transition of NiPAAm units. This study provides a new strategy for designing smart materials and surfaces with efficient responsiveness for biomedical applications. Promoting each other: Photo and thermo dual‐responsive surfaces are successfully constructed using poly(spiropyran‐co‐N‐isopropylacrylamide) to achieve highly efficient cell capture and release. This study provides a new strategy for the design of smart surfaces with high responsiveness.
ISSN:1439-4235
1439-7641
DOI:10.1002/cphc.201701145