Gene expression profiling in colorectal cancer using microarray technologies: Results and perspectives

Summary Nowadays molecular biology represents one of the most interesting topics in medical oncology, because it provides a global and detailed view on the molecular changes involved in tumour progression, leading to a better understanding of the carcinogenesis process, to discovering new prognostic...

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Bibliographic Details
Published in:Cancer treatment reviews 2009-05, Vol.35 (3), p.201-209
Main Authors: Nannini, Margherita, Pantaleo, Maria Abbondanza, Maleddu, Alessandra, Astolfi, Annalisa, Formica, Serena, Biasco, Guido
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemistry
Adenocarcinoma - drug therapy
Adenocarcinoma - genetics
Adenocarcinoma - secondary
Affymetrix
Antineoplastic Agents - therapeutic use
Carcinogenesis
Cell Transformation, Neoplastic
Colorectal cancer
Colorectal Neoplasms - chemistry
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
Disease Progression
DNA, Complementary - analysis
DNA, Neoplasm - genetics
Drug Monitoring - methods
Female
Forecasting
Gene Expression Profiling
Hematology, Oncology and Palliative Medicine
Humans
Liver metastases
Liver Neoplasms - secondary
Male
Medical Oncology - methods
Microarray
Neoplasm Proteins - analysis
Oligonucleotide Array Sequence Analysis
Prognosis
RNA, Messenger - analysis
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
RNA, Neoplasm - analysis
RNA, Neoplasm - biosynthesis
RNA, Neoplasm - genetics
Treatment Outcome
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Summary:Summary Nowadays molecular biology represents one of the most interesting topics in medical oncology, because it provides a global and detailed view on the molecular changes involved in tumour progression, leading to a better understanding of the carcinogenesis process, to discovering new prognostic markers and novel therapeutic targets. The gene expression profiling analysis with microarray technology has shown a great potential in cancer research and in medical oncology, mapping simultaneously the expression of thousands of genes in a single tumour sample and giving a measurement of articulated genes expression patterns. Colorectal cancer represents a wide and exciting area of research for molecular biology, due to the growing need of a molecular classification as well as prognostic and predictive molecular factors that may guide oncologists in patient’s clinical management. The aim of this review is to analyze the state of art of gene expression profile in colorectal cancer using microarrays technologies and to explore some perspectives in this research field.
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2008.10.006