High transplant-related mortality associated with haematopoietic stem cell transplantation for paediatric therapy-related acute myeloid leukaemia (t-AML). A study on behalf of the United Kingdom Paediatric Blood and Bone Marrow Transplant Group

Paediatric therapy-related acute myeloid leukaemia (t-AML) is rare and the outcome is poor. While allogeneic haematopoietic stem cell transplantation (HSCT) is generally the accepted modality of treatment, data regarding salvage chemotherapy, remission induction, conditioning regimens, transplant-re...

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Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) 2018-09, Vol.53 (9), p.1165-1169
Main Authors: Gassas, Adam, Sivaprakasam, Ponni, Cummins, Michelle, Breslin, Patricia, Patrick, Katharine, Slatter, Mary, Skinner, Roderick, Shenton, Geof, Gibson, Brenda, Lawson, Sarah, Petterson, Toni, Potter, Michael, James, Beki, Hough, Rachael, Hiwarkar, Prashant, Vora, Ajay, Veys, Paul, De La Fuente, Josu, Wynn, Robert, Amrolia, Persis
Format: Article
Language:English
Subjects:
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Acute myelocytic leukemia
Acute myeloid leukemia
Anthracyclines
Bone marrow
Bone marrow transplantation
Cancer
Care and treatment
Cell Biology
Chemotherapy
Children
Children's hospitals
Development and progression
Forecasts and trends
Hematology
Hematopoietic stem cell transplantation
Hematopoietic stem cells
Internal Medicine
Leukemia
Medicine
Medicine & Public Health
Methods
Mortality
Patient outcomes
Patients
Pediatrics
Public Health
Remission
Salvage
Stem cell transplantation
Stem Cells
Transplantation
Transplants & implants
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Summary:Paediatric therapy-related acute myeloid leukaemia (t-AML) is rare and the outcome is poor. While allogeneic haematopoietic stem cell transplantation (HSCT) is generally the accepted modality of treatment, data regarding salvage chemotherapy, remission induction, conditioning regimens, transplant-related mortality and outcome is scarce. Between 2000 and2016, 36 children with t-AML were treated in seven UK paediatric HSCT centres. The most common salvage protocol for remission induction was FLAG with or without idarubicin and 28 patients were in complete morphological remission prior to BMT. Only 12 patients survived (33%). Transplant-related mortality (TRM) was the leading cause of death.
ISSN:0268-3369
1476-5365
DOI:10.1038/s41409-018-0157-x