Phosphatidylserine-exposing blood cells and microparticles induce procoagulant activity in non-valvular atrial fibrillation

The definitive role of phosphatidylserine (PS) in the prothrombotic state of non-valvular atrial fibrillation (NVAF) remains unclear. Our objectives were to study the PS exposure on blood cells and microparticles (MPs) in NVAF, and evaluate their procoagulant activity (PCA). NVAF patients without (n...

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Bibliographic Details
Published in:International journal of cardiology 2018-05, Vol.258, p.138-143
Main Authors: Wang, Lixiu, Bi, Yayan, Yu, Muxin, Li, Tao, Tong, Dongxia, Yang, Xiaoyan, Zhang, Cong, Guo, Li, Wang, Chunxu, Kou, Yan, Dong, Zengxiang, Novakovic, Valerie A., Tian, Ye, Kou, Junjie, Shammas, Masood A., Shi, Jialan
Format: Article
Language:English
Subjects:
Blood cell
Microparticle
Non valvular atrial fibrillation
Phosphatidylserine
Procoagulant activity
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Summary:The definitive role of phosphatidylserine (PS) in the prothrombotic state of non-valvular atrial fibrillation (NVAF) remains unclear. Our objectives were to study the PS exposure on blood cells and microparticles (MPs) in NVAF, and evaluate their procoagulant activity (PCA). NVAF patients without (n = 60) and with left atrial thrombi (n = 18) and controls (n = 36) were included in our study. Exposed PS was analyzed with flow cytometry and confocal microscopy. PCA was evaluated using clotting time, factor Xa (FXa), thrombin and fibrin formation. PS+ blood cells and MPs were significantly higher in NVAF patients without and with left atrial thrombi (both P 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2018.01.116