Colitis with wall thickening and edematous changes during oral administration of the powdered form of Qing-dai in patients with ulcerative colitis: a report of two cases

Orally administered Qing-dai, called indigo naturalis in Latin, is reportedly useful for the treatment of ulcerative colitis. We herein describe two patients with ulcerative colitis who developed colitis with wall thickening and edematous changes during oral administration of the powdered form of Qi...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2018-08, Vol.11 (4), p.268-272
Main Authors: Kondo, Satoru, Araki, Toshimitsu, Okita, Yoshiki, Yamamoto, Akira, Hamada, Yasuhiko, Katsurahara, Masaki, Horiki, Noriyuki, Nakamura, Misaki, Shimoyama, Takahiro, Yamamoto, Takayuki, Takei, Yoshiyuki, Kusunoki, Masato
Format: Article
Language:English
Subjects:
Abdominal Surgery
Administration, Oral
Adult
Case Report
Colitis - chemically induced
Colitis - diagnostic imaging
Colitis - pathology
Colitis, Ulcerative - drug therapy
Colonoscopy
Colorectal Surgery
Drugs, Chinese Herbal - administration & dosage
Drugs, Chinese Herbal - adverse effects
Edema - chemically induced
Edema - diagnostic imaging
Edema - pathology
Female
Gastroenterology
Hepatology
Humans
Intestinal Mucosa - diagnostic imaging
Intestinal Mucosa - pathology
Male
Medicine
Medicine & Public Health
Powders
Recurrence
Surgical Oncology
Tomography, X-Ray Computed
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Summary:Orally administered Qing-dai, called indigo naturalis in Latin, is reportedly useful for the treatment of ulcerative colitis. We herein describe two patients with ulcerative colitis who developed colitis with wall thickening and edematous changes during oral administration of the powdered form of Qing-dai. In Case 1, a 35-year-old man developed colitis similar to ischemic colitis with bloody stool that recurred each time he ingested Qing-dai. He had no signs of recurrence upon withdrawal of Qing-dai. In Case 2, a 43-year-old woman underwent ileocecal resection for treatment of an intussusception 2 months after beginning oral administration of Qing-dai. Edema and congestion but no ulceration were present in the mucosa of the resected specimen. Both patients exhibited abdominal pain with bloody diarrhea, and abdominal computed tomography showed marked wall edema affecting an extensive portion of the large bowel.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-018-0851-7