Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics

Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance mechanisms to cancer therapy. This review describes the current knowledge regardi...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2018-04, Vol.124, p.29-36
Main Authors: Cardama, G.A., Alonso, D.F., Gonzalez, N., Maggio, J., Gomez, D.E., Rolfo, C., Menna, P.L
Format: Article
Language:English
Subjects:
Animals
Chemoresistance
Drug Resistance, Neoplasm - genetics
Humans
Immune evasion
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - radiotherapy
rac1 GTP-Binding Protein - physiology
Rac1 inhibition
Radiation Tolerance - genetics
Radioresistance
Signal Transduction - genetics
Targeted-therapy
Tumor Escape - genetics
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Summary:Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance mechanisms to cancer therapy. This review describes the current knowledge regarding Rac1 pathway deregulation and its association with chemoresistance, radioresistance, resistance to targeted therapies and immune evasion. This supports the idea that interfering Rac1 signaling pathway could be an interesting approach to tackle cancer resistance.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2018.01.012