Quercetin attenuates zymosan-induced arthritis in mice

•Quercetin reduces zymosan-induced articular pain.•Quercetin reduces zymosan-induced cytokine production and NF-κB activation.•Quercetin reduces oxidative stress induced by zymosan.•Quercetin activates Nrf2/HO-1 pathway in experimental arthritis. Rheumatoid arthritis (RA) is a chronic autoimmune dis...

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Published in:Biomedicine & pharmacotherapy 2018-06, Vol.102, p.175-184
Main Authors: Guazelli, Carla F.S., Staurengo-Ferrari, Larissa, Zarpelon, Ana C., Pinho-Ribeiro, Felipe A., Ruiz-Miyazawa, Kenji W., Vicentini, Fabiana T.M.C., Vignoli, Josiane A., Camilios-Neto, Doumit, Georgetti, Sandra R., Baracat, Marcela M., Casagrande, Rubia, Verri, Waldiceu A.
Format: Article
Language:English
Subjects:
Inflammation
NF-κB
Nrf2/heme Oxygenase (HO-1) pathway
Oxidative stress
Quercetin
Rheumatoid arthritis
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Summary:•Quercetin reduces zymosan-induced articular pain.•Quercetin reduces zymosan-induced cytokine production and NF-κB activation.•Quercetin reduces oxidative stress induced by zymosan.•Quercetin activates Nrf2/HO-1 pathway in experimental arthritis. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by articular lesions, recruitment of inflammatory cells and increased levels of pro-inflammatory cytokine. The intra-articular administration of zymosan is an experimental model that promotes inflammatory parameters resembling RA. Therefore, this model was used to investigate the efficacy of quercetin as a treatment of articular inflammation. Treatment with quercetin dose-dependently reduced zymosan-induced hyperalgesia, articular edema and the recruitment of neutrophils to the knee joint cavity. Histological analysis confirmed that quercetin inhibited zymosan-induced arthritis. The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFα and IL-1β production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression. These molecular effects of quercetin were related to the inhibition of the nuclear factor kappa-B and induction of Nuclear factor erythroid 2- related factor (Nrf2)/home oxygenase (HO-1) pathway. Thus, quercetin exerted anti-inflammatory, analgesic and antioxidant effects in experimental arthritis, suggesting quercetin is a possible candidate for arthritis treatment.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2018.03.057