Interictal regional paroxysmal fast activity on scalp EEG is common in patients with underlying gliosis

•Regional paroxysmal fast activity is present in 25% of patients with drug resistant focal epilepsy.•Regional paroxysmal fast activity is equally common in patients with gliosis and dysplasia.•Perinatal injury with gliosis is common cause for paroxysmal fast activity in developing countries. Interic...

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Bibliographic Details
Published in:Clinical neurophysiology 2018-05, Vol.129 (5), p.946-951
Main Authors: Dash, Gopal Krishna, Rathore, Chaturbhuj, Jeyaraj, Malcolm K., Wattamwar, Pandurang, Sarma, Sankara P., Radhakrishnan, Kurupath
Format: Article
Language:English
Subjects:
Drug resistant epilepsy
Focal cortical dysplasia
Gliosis
Regional paroxysmal fast activity
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Summary:•Regional paroxysmal fast activity is present in 25% of patients with drug resistant focal epilepsy.•Regional paroxysmal fast activity is equally common in patients with gliosis and dysplasia.•Perinatal injury with gliosis is common cause for paroxysmal fast activity in developing countries. Interictal regional paroxysmal fast activity (RPFA) on scalp EEG is common in patients with focal cortical dysplasia (FCD). Little data exists regarding the presence of RPFA in other etiologies. We studied the association between RPFA and etiology on MRI in patients with drug resistant focal epilepsy undergoing presurgical evaluation in 2011. RPFA was defined as ≥3 consecutive spikes with a frequency of ≥10 Hz lasting ≥300 ms but
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2018.02.007