Novel Production of Isochainin by a Strain of Streptomyces sp. Isolated from Rhizosphere Soil of the Indigenous Moroccan Plant Argania Spinosa L

An actinomycete strain (designated Ap1) isolated from the rhizosphere soil of Argania spinosa L. strongly inhibited the growth of two plant pathogens: Fusarium oxysporum f.sp. albedinis and Verticillium dahliae. The spore morphology suggested that the Ap1 strain belonged to the genus Streptomyces. T...

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Bibliographic Details
Published in:World journal of microbiology & biotechnology 2006-05, Vol.22 (5), p.423-429
Main Authors: Bouizgarne, B, El Hadrami, I, Ouhdouch, Y
Format: Article
Language:English
Subjects:
Antifungal
Bacteria
Biological and medical sciences
Biosynthesis
Biotechnology
Fundamental and applied biological sciences. Psychology
Fusarium oxysporum
Indigenous plants
isochainin
Liquid chromatography
macrolides
Mass spectroscopy
Microbiology
Rhizosphere
Streptomyces
Verticillium dahliae
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Summary:An actinomycete strain (designated Ap1) isolated from the rhizosphere soil of Argania spinosa L. strongly inhibited the growth of two plant pathogens: Fusarium oxysporum f.sp. albedinis and Verticillium dahliae. The spore morphology suggested that the Ap1 strain belonged to the genus Streptomyces. The antifungal compound produced by Ap1 was purified by HPLC and identified as the polyene macrolide, isochainin, by NMR and mass spectroscopy. Ap1 showed normal biosynthesis of isochainin in comparison with S. cellulosae ATTC 12625, in which precursor-directed biosynthesis by feeding ethyl (Z)-16-phenylhexadec-9-enoate to the culture medium is required. In addition, Streptomyces sp. strain Ap1 produces isochainin with a 6.5-fold higher concentration than Streptomyces cellulosae ATTC 12625.
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-005-9051-y