Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria

Bacteriocins are ribosomally synthesised small antimicrobial peptides produced from a wide range of bacteria, and also rich sources for potential alternatives to traditional antibiotics. Many bacteriocins have highly specific antibacterial activity against target pathogens, even including drug-resis...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2018-05, Vol.102 (10), p.4243-4253
Main Authors: Zheng, Sen, Sonomoto, Kenji
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Antibiotic resistance
Antibiotics
Antimicrobial peptides
Bacteria
Bacteriocins
Bacteriocins - genetics
Bacteriocins - metabolism
Bacteriocins - pharmacology
Biomedical and Life Sciences
Biosynthesis
Biotechnology
Chemistry, Pharmaceutical - trends
Drug resistance
Gram-positive bacteria
Gram-Positive Bacteria - physiology
Health aspects
Life Sciences
Membrane proteins
Membrane Transport Proteins - metabolism
Methicillin
Methicillin-Resistant Staphylococcus aureus - drug effects
Microbial Genetics and Genomics
Microbiology
Mini-Review
Peptides
Proteins
Secretion
Staphylococcus infections
Vancomycin
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Summary:Bacteriocins are ribosomally synthesised small antimicrobial peptides produced from a wide range of bacteria, and also rich sources for potential alternatives to traditional antibiotics. Many bacteriocins have highly specific antibacterial activity against target pathogens, even including drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus . As the final and essential step during biosynthesis, the leader sequence removal and exportation of matured bacteriocin are lacking of research and therefore the last to be understood. In respect of production, bacteriocin precursor peptides are processed and exported by a group of membrane proteins from the ATP-binding cassette transporter family. The main aims of this article are to summarise knowledge till now on the leader signal and correlated transporters for bacteriocin secretion in gram-positive bacteria in a review for the first time, to introduce different strategies for higher production, and to offer new insights into many essential but still unanswered questions above for the purpose of more efficient bacteriocin utilisation.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-018-8917-5