Characteristics of time-activity curves obtained from dynamic 11C-methionine PET in common primary brain tumors

Purpose The aim of this study was to assess whether dynamic PET with 11 C-methionine (MET) (MET-PET) is useful in the diagnosis of brain tumors. Methods One hundred sixty patients with brain tumors (139 gliomas, 9 meningiomas, 4 hemangioblastomas and 8 primary central nervous system lymphomas [PCNSL...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuro-oncology 2018-07, Vol.138 (3), p.649-658
Main Authors: Nomura, Yuichi, Asano, Yoshitaka, Shinoda, Jun, Yano, Hirohito, Ikegame, Yuka, Kawasaki, Tomohiro, Nakayama, Noriyuki, Maruyama, Takashi, Muragaki, Yoshihiro, Iwama, Toru
Format: Article
Language:English
Subjects:
Astrocytoma
Brain cancer
Brain tumors
Central nervous system
Clinical Study
Cortex (frontal)
Glioblastoma
Lymphoma
Medicine
Medicine & Public Health
Methionine
Neurology
Oncology
Positron emission tomography
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The aim of this study was to assess whether dynamic PET with 11 C-methionine (MET) (MET-PET) is useful in the diagnosis of brain tumors. Methods One hundred sixty patients with brain tumors (139 gliomas, 9 meningiomas, 4 hemangioblastomas and 8 primary central nervous system lymphomas [PCNSL]) underwent dynamic MET-PET with a 3-dimensional acquisition mode, and the maximum tumor MET-standardized uptake value (MET-SUV) was measured consecutively to construct a time-activity curve (TAC). Furthermore, receiver operating characteristic (ROC) curves were generated from the time-to-peak (TTP) and the slope of the curve in the late phase (SLOPE). Results The TAC patterns of MET-SUVs (MET-TACs) could be divided into four characteristic types when MET dynamics were analyzed by dividing the MET-TAC into three phases. MET-SUVs were significantly higher in early and late phases in glioblastoma compared to anaplastic astrocytoma, diffuse astrocytoma and the normal frontal cortex (P 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-018-2834-4